Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Ultraviolet radiation drives mutations in a subset of mucosal melanomas

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. cyCombine allows for robust integration of single-cell cytometry datasets within and across technologies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Serum metabolome associated with severity of acute traumatic brain injury

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. IL-4 and IL-13 both contribute to the homeostasis of human conjunctival goblet cells in vitro

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Mutation of KRAS in colorectal adenocarcinoma in Greenland

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Investigation of the correlation between diabetic retinopathy and prevalent and incident migraine in a national cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Nationwide Incidence of Thyroid Eye Disease and Cumulative Incidence of Strabismus and Surgical Interventions in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Piyushkumar A Mundra
  • Nathalie Dhomen
  • Manuel Rodrigues
  • Lauge Hjorth Mikkelsen
  • Nathalie Cassoux
  • Kelly Brooks
  • Sara Valpione
  • Jorge S Reis-Filho
  • Steffen Heegaard
  • Marc-Henri Stern
  • Sergio Roman-Roman
  • Richard Marais
Vis graf over relationer

Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 mucosal melanomas of conjunctival origin by whole genome sequencing and our data shows a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal melanomas with SBS7 dominance have similar genomic patterns to cutaneous melanomas and therefore this subset should not be excluded from treatments currently used for common cutaneous melanoma.

OriginalsprogEngelsk
Artikelnummer259
TidsskriftNature Communications
Vol/bind12
Udgave nummer1
Antal sider7
DOI
StatusUdgivet - dec. 2021

Bibliografisk note

Funding Information:
R.M. is supported by Wellcome Trust (100282/Z/12/Z), European Research Council (ERC-ADG-2014 671262), Cancer Research UK (A27412 and A22902). M.R. and M.-H.S. are funded by Institut Curie, the Ligue Nationale Contre le Cancer (Labellisa-tion), and Site de Recherche Intégrée sur le Cancer (SiRIC) de l’Institut Curie. M.-H.S. is also funded by Institut National de la Santé et de la Recherche Médicale. R.M., M.-H.S., and S.R. are supported by the European Commission under the Horizon 2020 program (U.M. Cure; project number: 667787). L.H.M. was funded by a non-restricted Candys Foundation grant. J.S.R.-F. is funded in part the Breast Cancer Research Foundation. S.V.

Funding Information:
is supported by a Harry J Lloyd Charitable Trust Career Development Award. WGS costs were partly supported by the Manchester NIHR Biomedical Research Centre.

ID: 61960171