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Type 2 diabetes and pre-diabetic abnormalities in patients with bipolar disorders

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Harvard

Leopold, K, Reif, A, Haack, S, Bauer, M, Bury, D, Löffler, A, Kittel-Schneider, S, Pfeiffer, S, Sauer, C, Schwarz, P & Pfennig, A 2016, 'Type 2 diabetes and pre-diabetic abnormalities in patients with bipolar disorders', Journal of Affective Disorders, bind 189, s. 240-5. https://doi.org/10.1016/j.jad.2015.09.041

APA

Leopold, K., Reif, A., Haack, S., Bauer, M., Bury, D., Löffler, A., Kittel-Schneider, S., Pfeiffer, S., Sauer, C., Schwarz, P., & Pfennig, A. (2016). Type 2 diabetes and pre-diabetic abnormalities in patients with bipolar disorders. Journal of Affective Disorders, 189, 240-5. https://doi.org/10.1016/j.jad.2015.09.041

CBE

Leopold K, Reif A, Haack S, Bauer M, Bury D, Löffler A, Kittel-Schneider S, Pfeiffer S, Sauer C, Schwarz P, Pfennig A. 2016. Type 2 diabetes and pre-diabetic abnormalities in patients with bipolar disorders. Journal of Affective Disorders. 189:240-5. https://doi.org/10.1016/j.jad.2015.09.041

MLA

Vancouver

Author

Leopold, Karolina ; Reif, Andreas ; Haack, Sarah ; Bauer, Michael ; Bury, Daniel ; Löffler, Antje ; Kittel-Schneider, Sarah ; Pfeiffer, Steffi ; Sauer, Cathrin ; Schwarz, Peter ; Pfennig, Andrea. / Type 2 diabetes and pre-diabetic abnormalities in patients with bipolar disorders. I: Journal of Affective Disorders. 2016 ; Bind 189. s. 240-5.

Bibtex

@article{43bde68bc6a44c1db7dd2193f9a12fea,
title = "Type 2 diabetes and pre-diabetic abnormalities in patients with bipolar disorders",
abstract = "BACKGROUND: Abnormalities in the glucose metabolism cause nervous and organic damage and are a cardiovascular risk factor. They could be a main cause for the increased morbidity and mortality rates found in patients with bipolar disorders. The exact prevalence of diabetes and pre-diabetic abnormalities, however, is not clear.METHODS: 85 euthymic outpatients with bipolar disorders from two university hospitals in Germany underwent an oral glucose tolerance test, laboratory screening and clinical measurements. Socio-demographic data, medication, severity of illness, global functioning and life quality were assessed.RESULTS: Diabetes mellitus was found in 7% of the patients, pre-diabetic abnormalities in 27%. The group of patients with abnormalities in the glucose metabolism had significantly lower quality of life and global functioning. Higher BMI, leptin, triglycerides and CRP levels significantly increased the likelihood for pre-diabetes/diabetes.LIMITATIONS: The low sample size did only allow limited assessment of impact of medication on the results. No healthy controls were assessed.CONCLUSIONS: One-third of the patients with bipolar disorders showed abnormalities in the glucose metabolism and this was associated with impaired global functioning and lower quality of life. Early detection and intervention strategies fitting the needs of patient with bipolar disorder are needed to improve both physical and mental health.",
author = "Karolina Leopold and Andreas Reif and Sarah Haack and Michael Bauer and Daniel Bury and Antje L{\"o}ffler and Sarah Kittel-Schneider and Steffi Pfeiffer and Cathrin Sauer and Peter Schwarz and Andrea Pfennig",
note = "Copyright {\textcopyright} 2015 Elsevier B.V. All rights reserved.",
year = "2016",
month = jan,
day = "1",
doi = "10.1016/j.jad.2015.09.041",
language = "English",
volume = "189",
pages = "240--5",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Type 2 diabetes and pre-diabetic abnormalities in patients with bipolar disorders

AU - Leopold, Karolina

AU - Reif, Andreas

AU - Haack, Sarah

AU - Bauer, Michael

AU - Bury, Daniel

AU - Löffler, Antje

AU - Kittel-Schneider, Sarah

AU - Pfeiffer, Steffi

AU - Sauer, Cathrin

AU - Schwarz, Peter

AU - Pfennig, Andrea

N1 - Copyright © 2015 Elsevier B.V. All rights reserved.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - BACKGROUND: Abnormalities in the glucose metabolism cause nervous and organic damage and are a cardiovascular risk factor. They could be a main cause for the increased morbidity and mortality rates found in patients with bipolar disorders. The exact prevalence of diabetes and pre-diabetic abnormalities, however, is not clear.METHODS: 85 euthymic outpatients with bipolar disorders from two university hospitals in Germany underwent an oral glucose tolerance test, laboratory screening and clinical measurements. Socio-demographic data, medication, severity of illness, global functioning and life quality were assessed.RESULTS: Diabetes mellitus was found in 7% of the patients, pre-diabetic abnormalities in 27%. The group of patients with abnormalities in the glucose metabolism had significantly lower quality of life and global functioning. Higher BMI, leptin, triglycerides and CRP levels significantly increased the likelihood for pre-diabetes/diabetes.LIMITATIONS: The low sample size did only allow limited assessment of impact of medication on the results. No healthy controls were assessed.CONCLUSIONS: One-third of the patients with bipolar disorders showed abnormalities in the glucose metabolism and this was associated with impaired global functioning and lower quality of life. Early detection and intervention strategies fitting the needs of patient with bipolar disorder are needed to improve both physical and mental health.

AB - BACKGROUND: Abnormalities in the glucose metabolism cause nervous and organic damage and are a cardiovascular risk factor. They could be a main cause for the increased morbidity and mortality rates found in patients with bipolar disorders. The exact prevalence of diabetes and pre-diabetic abnormalities, however, is not clear.METHODS: 85 euthymic outpatients with bipolar disorders from two university hospitals in Germany underwent an oral glucose tolerance test, laboratory screening and clinical measurements. Socio-demographic data, medication, severity of illness, global functioning and life quality were assessed.RESULTS: Diabetes mellitus was found in 7% of the patients, pre-diabetic abnormalities in 27%. The group of patients with abnormalities in the glucose metabolism had significantly lower quality of life and global functioning. Higher BMI, leptin, triglycerides and CRP levels significantly increased the likelihood for pre-diabetes/diabetes.LIMITATIONS: The low sample size did only allow limited assessment of impact of medication on the results. No healthy controls were assessed.CONCLUSIONS: One-third of the patients with bipolar disorders showed abnormalities in the glucose metabolism and this was associated with impaired global functioning and lower quality of life. Early detection and intervention strategies fitting the needs of patient with bipolar disorder are needed to improve both physical and mental health.

U2 - 10.1016/j.jad.2015.09.041

DO - 10.1016/j.jad.2015.09.041

M3 - Journal article

C2 - 26451510

VL - 189

SP - 240

EP - 245

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 46169834