Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{bbcde88f0b9b4716b55d7187986f8bd8,
title = "Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints",
abstract = "INTRODUCTION: Human papilloma virus (HPV) vaccine uptake in girls and women is dropping markedly in some countries. Concern about the presumed side effects is the commonest reason why. Reports about side effects include specific sleep complaints such as excessive daytime sleepiness, altered dream activity and periods of muscle weakness. These symptoms are commonly seen in individuals with narcolepsy type 1. We aimed to evaluate whether HPV vaccination was associated with the development of hypocretin-deficient narcolepsy.METHODS: We report the evaluation for sleep disorders, including narcolepsy, in 29 HPV-vaccinated girls and women who were submitted for evaluation of narcolepsy. All were evaluated by polysomnography and the Multiple Sleep Latency Test, and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.RESULTS: None of the 29 girls and women showed signs of narcolepsy type 1.CONCLUSION: Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.FUNDING: none.TRIAL REGISTRATION: not relevant.",
author = "Torstensen, {Eva Wiberg} and Brinth, {Louise Schouborg} and Jesper Mehlsen and Kornum, {Birgitte Rahbek} and Jennum, {Poul J{\o}rgensen}",
note = "Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.",
year = "2018",
month = "11",
language = "English",
volume = "65",
pages = "A6511",
journal = "Danish Medical Bulletin (Online)",
issn = "1603-9629",
publisher = "Almindelige Danske Laegeforening",
number = "11",

}

RIS

TY - JOUR

T1 - Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints

AU - Torstensen, Eva Wiberg

AU - Brinth, Louise Schouborg

AU - Mehlsen, Jesper

AU - Kornum, Birgitte Rahbek

AU - Jennum, Poul Jørgensen

N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2018/11

Y1 - 2018/11

N2 - INTRODUCTION: Human papilloma virus (HPV) vaccine uptake in girls and women is dropping markedly in some countries. Concern about the presumed side effects is the commonest reason why. Reports about side effects include specific sleep complaints such as excessive daytime sleepiness, altered dream activity and periods of muscle weakness. These symptoms are commonly seen in individuals with narcolepsy type 1. We aimed to evaluate whether HPV vaccination was associated with the development of hypocretin-deficient narcolepsy.METHODS: We report the evaluation for sleep disorders, including narcolepsy, in 29 HPV-vaccinated girls and women who were submitted for evaluation of narcolepsy. All were evaluated by polysomnography and the Multiple Sleep Latency Test, and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.RESULTS: None of the 29 girls and women showed signs of narcolepsy type 1.CONCLUSION: Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.FUNDING: none.TRIAL REGISTRATION: not relevant.

AB - INTRODUCTION: Human papilloma virus (HPV) vaccine uptake in girls and women is dropping markedly in some countries. Concern about the presumed side effects is the commonest reason why. Reports about side effects include specific sleep complaints such as excessive daytime sleepiness, altered dream activity and periods of muscle weakness. These symptoms are commonly seen in individuals with narcolepsy type 1. We aimed to evaluate whether HPV vaccination was associated with the development of hypocretin-deficient narcolepsy.METHODS: We report the evaluation for sleep disorders, including narcolepsy, in 29 HPV-vaccinated girls and women who were submitted for evaluation of narcolepsy. All were evaluated by polysomnography and the Multiple Sleep Latency Test, and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.RESULTS: None of the 29 girls and women showed signs of narcolepsy type 1.CONCLUSION: Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.FUNDING: none.TRIAL REGISTRATION: not relevant.

M3 - Journal article

VL - 65

SP - A6511

JO - Danish Medical Bulletin (Online)

JF - Danish Medical Bulletin (Online)

SN - 1603-9629

IS - 11

ER -

ID: 55616987