Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Post-operative recovery is not a limiting factor for adjuvant chemotherapy in patients undergoing surgery for colorectal cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Multivitamin intake does not affect the risk of preterm and very preterm birth

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Time from injury to arrival at the trauma centre in patients undergoing interhospital transfer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Face masks for the prevention of COVID-19 - Rationale and design of the randomised controlled trial DANMASK-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Nusinersen treatment of spinal muscular atrophy - a systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Characterization of Blood Pressure and Heart Rate Oscillations in POTS Patients via Uniform Phase Empirical Mode Decomposition

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Robust, ECG-based detection of Sleep-disordered breathing in large population-based cohorts

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

INTRODUCTION: Human papilloma virus (HPV) vaccine uptake in girls and women is dropping markedly in some countries. Concern about the presumed side effects is the commonest reason why. Reports about side effects include specific sleep complaints such as excessive daytime sleepiness, altered dream activity and periods of muscle weakness. These symptoms are commonly seen in individuals with narcolepsy type 1. We aimed to evaluate whether HPV vaccination was associated with the development of hypocretin-deficient narcolepsy.

METHODS: We report the evaluation for sleep disorders, including narcolepsy, in 29 HPV-vaccinated girls and women who were submitted for evaluation of narcolepsy. All were evaluated by polysomnography and the Multiple Sleep Latency Test, and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.

RESULTS: None of the 29 girls and women showed signs of narcolepsy type 1.

CONCLUSION: Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.

FUNDING: none.

TRIAL REGISTRATION: not relevant.

OriginalsprogEngelsk
TidsskriftDanish Medical Journal
Vol/bind65
Udgave nummer11
Sider (fra-til)A6511
ISSN1603-9629
StatusUdgivet - nov. 2018

ID: 55616987