Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Trends in hysterectomy-corrected uterine cancer mortality rates during 2002 to 2015: mortality of nonendometrioid cancer on the rise?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Common gene variants within 3'-untranslated regions as modulators of multiple myeloma risk and survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Gastrointestinal toxicity during induction treatment for childhood acute lymphoblastic leukemia: The impact of the gut microbiota

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of specific types of ovarian cancer after borderline ovarian tumors in Denmark: A nationwide study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Risk of cervical intraepithelial neoplasia grade 2 or worse after conization in relation to HPV vaccination status

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Line W Gustafson
  • Berit B Booth
  • Johnny Kahlert
  • Gitte Ørtoft
  • Else Mejlgaard
  • Megan A Clarke
  • Nicolas Wentzensen
  • Anne F Rositch
  • Anne Hammer
Vis graf over relationer

Corpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy-corrected mortality rates of corpus uteri cancer, overall and stratified by age, stage and histologic subtype. Using data from nationwide Danish registries, we calculated uncorrected and hysterectomy-corrected age-standardized mortality rates of corpus uteri cancer among women ≥35 years during 2002 to 2015. Individual-level hysterectomy status was obtained from national registries; hysterectomy-corrected mortality rates were calculated by subtracting posthysterectomy person-years from the denominator, unless hysterectomy was performed due to corpus uteri cancer. Correction for hysterectomy resulted in a 25.5% higher mortality rate (12.3/100000 person-years vs 9.8/100000 person-years). Mortality rates were highest in women aged 70+, irrespective of year of death, histologic subtype and stage. A significant decline was observed in overall hysterectomy-corrected mortality rates from 2002 to 2015, particularly among women aged 70+. Mortality rates of endometrioid cancer declined significantly over time (annual percent change [APC]: -2.32, 95% CI -3.9, -0.7, P = .01), whereas rates of nonendometrioid cancer increased (APC: 5.90, 95% CI: 3.0, 8.9, P < .001). With respect to stage, mortality rates increased significantly over time for FIGOI-IIa (APC: 6.18 [95% CI: 1.9, 10.7] P = .01) but remained unchanged for FIGO IIb-IV. In conclusion, increasing mortality rates of nonendometrioid cancer paralleled the previously observed rise in incidence rates of this histologic subtype. Given the poor prognosis of nonendometrioid cancer, more studies are needed to clarify the underlying reason for these findings.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind148
Udgave nummer3
Sider (fra-til)584-592
Antal sider9
ISSN0020-7136
DOI
StatusUdgivet - 1 feb. 2021

Bibliografisk note

© 2020 Union for International Cancer Control.

ID: 61425314