Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Total and central adiposity are associated with age at gonadarche and incidence of precocious gonadarche in boys

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The calcium-sensing receptor is essential for calcium and bicarbonate sensitivity in human spermatozoa

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Establishment of a novel human fetal adrenal culture model that supports de novo and manipulated steroidogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Impact of Lean Body Mass and Insulin Sensitivity on the IGF-1-Bone Mass Axis in Adolescence: the EPICOM study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Male fertility before and after androgen abuse

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Does height and IGF-I determine pubertal timing in girls?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Marked increase in incident gynecomastia: a 20-year national registry study, 1998 to 2017

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Trends in the Incidence of Central Precocious Puberty and Normal Variant Puberty Among Children in Denmark, 1998 to 2017

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Anogenital distance in healthy Infants:Method-, age- and sex-related reference ranges

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Reproductive Hormones During Pubertal Transition in Girls with Transient Thelarche

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Ana Pereira
  • Alexander S Busch
  • Fernanda Solares
  • Ingrid Baier
  • Camila Corvalan
  • Veronica Mericq
Vis graf over relationer

CONTEXT: A close link between body mass index (BMI) and female pubertal onset is well established. However, observations in boys remain inconclusive.

OBJECTIVE: We aim to determine whether BMI as well as total and central adiposity in prepubertal Chilean boys is associated with pubertal timing.

METHODS: We performed a longitudinal study in which 494 boys from the Growth and Obesity Chilean Cohort Study were followed starting from birth and throughout puberty, including 5 prepubertal visits. The main outcome measures included anthropometric data and semi-annual clinical pubertal staging. The association between BMI, obesity (BMI standard deviation score [SDS] ≥ 2) and central adiposity (waist circumference ≥ 90th centile) with precocious puberty and age at gonadarche was analyzed using survival- and logistic regression models.

RESULTS: BMI, prevalence of total obesity, and central obesity increased throughout childhood. Among the study population, 45 boys entered puberty before the age of 9 years (9.1%). Obesity at 4 to 7 years and childhood mean BMI SDS were significantly associated with precocious gonadarche. Mean age at testicular enlargement (≥4 mL), was 11.0 years (95% CI, 10.9-11.1) and was inversely associated with BMI SDS, waist circumference, and percentage fat mass in almost all prepubertal visits. Age at testicular enlargement in normal weight, overweight, and obese boys was 11.2 (11.0-11.3), 10.9 (10.6-11.1) and 10.7 (10.4-11.1) years, respectively.

CONCLUSION: Our observation supports the association of BMI SDS and obesity with pubertal timing and precocious gonadarche in boys, respectively. Early intervention controlling the obesity epidemic could be useful in decreasing detrimental impact on later health.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
Vol/bind106
Udgave nummer5
Sider (fra-til)1352-1361
Antal sider10
ISSN0021-972X
DOI
StatusUdgivet - 23 apr. 2021

Bibliografisk note

© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

ID: 62062096