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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

The total pregnancy potential per oocyte aspiration after assisted reproduction-in how many cycles are biologically competent oocytes available?

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DOI

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  2. Transcription profile of the insulin-like growth factor signaling pathway during human ovarian follicular development

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  3. Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization

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  4. Cryopreservation of ovarian tissue may be considered in young girls with galactosemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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PURPOSE: While stimulation of women prior to assisted reproduction is associated with increased success rates, the total biological pregnancy potential per stimulation cycle is rarely assessed.

METHODS: Retrospective sequential cohort study of the cumulative live birth rate in 1148 first IVF/ICSI-cycles and 5-year follow up of frozen embryo replacement (FER) cycles were used. Oocyte number, number of embryos transferred, and cryopreserved/thawed and transferred embryos in a FER cycle were registered for all patients. Children per oocyte and per transferred embryo and percentage of cycles with births were calculated.

RESULTS: We obtained 9529 oocytes. Embryos (2507) were transferred in either fresh or FER cycles, resulting in 422 births and 474 live born children. Median age of the women was 32.5 years (range 20-41.5 years). In total, 34.3 % of all cycles ended with a live birth while in 65.7 % of the cycles, no oocytes were capable of developing into a child. The average number of oocytes needed per live born child after transfer of fresh and thawed embryos was 20 as only 5.0 % of oocytes aspirated in the first IVF/ICSI cycle had the competence to develop into a child.

CONCLUSIONS: In our setting, overall 5.0 % of the oocytes in a first cycle were biologically competent and in around 2/3 of all cycles, none of the oocytes had the potential to result in the birth of a child.

OriginalsprogEngelsk
TidsskriftJournal of Assisted Reproduction and Genetics
Vol/bind33
Udgave nummer7
Sider (fra-til)849-54
Antal sider6
ISSN1058-0468
DOI
StatusUdgivet - jul. 2016

ID: 49873916