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The Role of Leptin in Fetal Growth during Pre-Eclampsia

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  • Victoria E de Knegt
  • Paula L Hedley
  • Jørgen K Kanters
  • Ida N Thagaard
  • Lone Krebs
  • Michael Christiansen
  • Ulrik Lausten-Thomsen
Vis graf over relationer

Leptin is secreted by the placenta and has a multi-facetted role in the regulation of functions related to pregnancy. Metabolic disorders and insufficient homeostatic compensatory mechanisms involving leptin during pregnancy play a decisive role in the development of pre-eclampsia (PE) and give rise to compromised intrauterine growth conditions and aberrant birth weight of offspring. This review was compiled to elucidate the metabolic background of PE and its relationship with adverse intrauterine growth conditions through the examination of leptin as well as to describe possible mechanisms linking leptin to fetal growth restriction. This review illustrates that leptin in PE is dysregulated in maternal, fetal, and placental compartments. There is no single set of unifying mechanisms within the spectrum of PE, and regulatory mechanisms involving leptin are specific to each situation. We conclude that dysregulated leptin is involved in fetal growth at many levels through complex interactions with parallel pregnancy systems and probably throughout the entirety of pregnancy.

OriginalsprogEngelsk
Artikelnummer4569
TidsskriftInternational Journal of Molecular Sciences
Vol/bind22
Udgave nummer9
Sider (fra-til)1-16
Antal sider16
ISSN1661-6596
DOI
StatusUdgivet - 27 apr. 2021

ID: 65428511