Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Kristensen, D, Nielsen, LB, Roug, AS, Kristensen, T-CC, El-Galaly, TC, Nørgaard, JM, Marcher, CW, Schöllkopf, C, Theilgaard-Mönch, K & Severinsen, MT 2020, 'The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study', British Journal of Haematology, bind 190, nr. 2, s. 236-243. https://doi.org/10.1111/bjh.16667

APA

Kristensen, D., Nielsen, L. B., Roug, A. S., Kristensen, T-C. C., El-Galaly, T. C., Nørgaard, J. M., Marcher, C. W., Schöllkopf, C., Theilgaard-Mönch, K., & Severinsen, M. T. (2020). The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study. British Journal of Haematology, 190(2), 236-243. https://doi.org/10.1111/bjh.16667

CBE

MLA

Vancouver

Author

Kristensen, Daniel ; Nielsen, Lars B ; Roug, Anne Stidsholt ; Kristensen, Tove-Christina C ; El-Galaly, Tarec C ; Nørgaard, Jan M ; Marcher, Claus W ; Schöllkopf, Claudia ; Theilgaard-Mönch, Kim ; Severinsen, Marianne T. / The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study. I: British Journal of Haematology. 2020 ; Bind 190, Nr. 2. s. 236-243.

Bibtex

@article{8934bcdfb04c45919da2d0480d0286a5,
title = "The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study",
abstract = "With rising life expectancy, the importance of patient-related prognostic factors and how to integrate such data into clinical decision-making becomes increasingly important. The aim of this study was to evaluate the prognostic impact of smoking status in patients with acute myeloid leukaemia (AML) treated with intensive chemotherapy. We conducted a nationwide cohort study based on data obtained from the Danish National Leukaemia Registry (DNLR). The study comprised Danish patients aged 18-75 years, diagnosed with AML between 1 January 2000 and 31 December 2012. Medical records were reviewed and data on smoking status were collected. A total of 1040 patients (median age 59 years) were included, and 602 patients (58·9%) were categorised as ever-smokers and the remaining as never-smokers. Kaplan-Meier survival estimates revealed that ever-smokers had a significant shorter median overall survival (OS) at 17·2 months [95% CI (14·9;19·1)] compared to never-smokers at 24·5 months (95% CI [19·2;30·7]). Multivariate analysis revealed smoking status as a significant prognostic factor for inferior OS with a hazard ratio (HR) of 1·22 [95% CI (1·04;1·44)]. In conclusion, smoking status was found to be associated with inferior OS in intensively treated AML patients.",
keywords = "acute myeloid leukaemia, AML, lifestyle factors, population, prognosis, tobacco-smoking",
author = "Daniel Kristensen and Nielsen, {Lars B} and Roug, {Anne Stidsholt} and Kristensen, {Tove-Christina C} and El-Galaly, {Tarec C} and N{\o}rgaard, {Jan M} and Marcher, {Claus W} and Claudia Sch{\"o}llkopf and Kim Theilgaard-M{\"o}nch and Severinsen, {Marianne T}",
note = "{\textcopyright} 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",
year = "2020",
month = apr,
day = "21",
doi = "10.1111/bjh.16667",
language = "English",
volume = "190",
pages = "236--243",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study

AU - Kristensen, Daniel

AU - Nielsen, Lars B

AU - Roug, Anne Stidsholt

AU - Kristensen, Tove-Christina C

AU - El-Galaly, Tarec C

AU - Nørgaard, Jan M

AU - Marcher, Claus W

AU - Schöllkopf, Claudia

AU - Theilgaard-Mönch, Kim

AU - Severinsen, Marianne T

N1 - © 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

PY - 2020/4/21

Y1 - 2020/4/21

N2 - With rising life expectancy, the importance of patient-related prognostic factors and how to integrate such data into clinical decision-making becomes increasingly important. The aim of this study was to evaluate the prognostic impact of smoking status in patients with acute myeloid leukaemia (AML) treated with intensive chemotherapy. We conducted a nationwide cohort study based on data obtained from the Danish National Leukaemia Registry (DNLR). The study comprised Danish patients aged 18-75 years, diagnosed with AML between 1 January 2000 and 31 December 2012. Medical records were reviewed and data on smoking status were collected. A total of 1040 patients (median age 59 years) were included, and 602 patients (58·9%) were categorised as ever-smokers and the remaining as never-smokers. Kaplan-Meier survival estimates revealed that ever-smokers had a significant shorter median overall survival (OS) at 17·2 months [95% CI (14·9;19·1)] compared to never-smokers at 24·5 months (95% CI [19·2;30·7]). Multivariate analysis revealed smoking status as a significant prognostic factor for inferior OS with a hazard ratio (HR) of 1·22 [95% CI (1·04;1·44)]. In conclusion, smoking status was found to be associated with inferior OS in intensively treated AML patients.

AB - With rising life expectancy, the importance of patient-related prognostic factors and how to integrate such data into clinical decision-making becomes increasingly important. The aim of this study was to evaluate the prognostic impact of smoking status in patients with acute myeloid leukaemia (AML) treated with intensive chemotherapy. We conducted a nationwide cohort study based on data obtained from the Danish National Leukaemia Registry (DNLR). The study comprised Danish patients aged 18-75 years, diagnosed with AML between 1 January 2000 and 31 December 2012. Medical records were reviewed and data on smoking status were collected. A total of 1040 patients (median age 59 years) were included, and 602 patients (58·9%) were categorised as ever-smokers and the remaining as never-smokers. Kaplan-Meier survival estimates revealed that ever-smokers had a significant shorter median overall survival (OS) at 17·2 months [95% CI (14·9;19·1)] compared to never-smokers at 24·5 months (95% CI [19·2;30·7]). Multivariate analysis revealed smoking status as a significant prognostic factor for inferior OS with a hazard ratio (HR) of 1·22 [95% CI (1·04;1·44)]. In conclusion, smoking status was found to be associated with inferior OS in intensively treated AML patients.

KW - acute myeloid leukaemia

KW - AML

KW - lifestyle factors

KW - population

KW - prognosis

KW - tobacco-smoking

UR - http://www.scopus.com/inward/record.url?scp=85083739303&partnerID=8YFLogxK

U2 - 10.1111/bjh.16667

DO - 10.1111/bjh.16667

M3 - Journal article

C2 - 32316076

VL - 190

SP - 236

EP - 243

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -

ID: 60188811