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The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

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Harvard

Razavi, H, Waked, I, Sarrazin, C, Myers, RP, Idilman, R, Calinas, F, Vogel, W, Mendes Correa, MC, Hézode, C, Lázaro, P, Akarca, U, Aleman, S, Balık, I, Berg, T, Bihl, F, Bilodeau, M, Blasco, AJ, Brandão Mello, CE, Bruggmann, P, Buti, M, Calleja, JL, Cheinquer, H, Christensen, PB, Clausen, M, Coelho, HSM, Cramp, ME, Dore, GJ, Doss, W, Duberg, AS, El-Sayed, MH, Ergör, G, Esmat, G, Falconer, K, Félix, J, Ferraz, MLG, Ferreira, PR, Frankova, S, García-Samaniego, J, Gerstoft, J, Giria, JA, Gonçales, FL, Gower, E, Gschwantler, M, Guimarães Pessôa, M, Hindman, SJ, Hofer, H, Husa, P, Kåberg, M, Kaita, KDE, Kautz, A, Kaymakoglu, S, Krajden, M, Krarup, H, Laleman, W, Lavanchy, D, Marinho, RT, Marotta, P, Mauss, S, Moreno, C, Murphy, K, Negro, F, Nemecek, V, Örmeci, N, Øvrehus, ALH, Parkes, J, Pasini, K, Peltekian, KM, Ramji, A, Reis, N, Roberts, SK, Rosenberg, WM, Roudot-Thoraval, F, Ryder, SD, Sarmento-Castro, R, Semela, D, Sherman, M, Shiha, GE, Sievert, W, Sperl, J, Stärkel, P, Stauber, RE, Thompson, AJ, Urbanek, P, Van Damme, P, van Thiel, I, Van Vlierberghe, H, Vandijck, D, Wedemeyer, H, Weis, N, Wiegand, J, Yosry, A, Zekry, A, Cornberg, M, Müllhaupt, B & Estes, C 2014, 'The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm' Journal of Viral Hepatitis, bind 21 Suppl 1, s. 34-59. https://doi.org/10.1111/jvh.12248

APA

Razavi, H., Waked, I., Sarrazin, C., Myers, R. P., Idilman, R., Calinas, F., ... Estes, C. (2014). The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm. Journal of Viral Hepatitis, 21 Suppl 1, 34-59. https://doi.org/10.1111/jvh.12248

CBE

Razavi H, Waked I, Sarrazin C, Myers RP, Idilman R, Calinas F, Vogel W, Mendes Correa MC, Hézode C, Lázaro P, Akarca U, Aleman S, Balık I, Berg T, Bihl F, Bilodeau M, Blasco AJ, Brandão Mello CE, Bruggmann P, Buti M, Calleja JL, Cheinquer H, Christensen PB, Clausen M, Coelho HSM, Cramp ME, Dore GJ, Doss W, Duberg AS, El-Sayed MH, Ergör G, Esmat G, Falconer K, Félix J, Ferraz MLG, Ferreira PR, Frankova S, García-Samaniego J, Gerstoft J, Giria JA, Gonçales FL, Gower E, Gschwantler M, Guimarães Pessôa M, Hindman SJ, Hofer H, Husa P, Kåberg M, Kaita KDE, Kautz A, Kaymakoglu S, Krajden M, Krarup H, Laleman W, Lavanchy D, Marinho RT, Marotta P, Mauss S, Moreno C, Murphy K, Negro F, Nemecek V, Örmeci N, Øvrehus ALH, Parkes J, Pasini K, Peltekian KM, Ramji A, Reis N, Roberts SK, Rosenberg WM, Roudot-Thoraval F, Ryder SD, Sarmento-Castro R, Semela D, Sherman M, Shiha GE, Sievert W, Sperl J, Stärkel P, Stauber RE, Thompson AJ, Urbanek P, Van Damme P, van Thiel I, Van Vlierberghe H, Vandijck D, Wedemeyer H, Weis N, Wiegand J, Yosry A, Zekry A, Cornberg M, Müllhaupt B, Estes C. 2014. The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm. Journal of Viral Hepatitis. 21 Suppl 1:34-59. https://doi.org/10.1111/jvh.12248

MLA

Vancouver

Author

Razavi, H ; Waked, I ; Sarrazin, C ; Myers, R P ; Idilman, R ; Calinas, F ; Vogel, W ; Mendes Correa, M C ; Hézode, C ; Lázaro, P ; Akarca, U ; Aleman, S ; Balık, I ; Berg, T ; Bihl, F ; Bilodeau, M ; Blasco, A J ; Brandão Mello, C E ; Bruggmann, P ; Buti, M ; Calleja, J L ; Cheinquer, H ; Christensen, P B ; Clausen, M ; Coelho, H S M ; Cramp, M E ; Dore, G J ; Doss, W ; Duberg, A S ; El-Sayed, M H ; Ergör, G ; Esmat, G ; Falconer, K ; Félix, J ; Ferraz, M L G ; Ferreira, P R ; Frankova, S ; García-Samaniego, J ; Gerstoft, J ; Giria, J A ; Gonçales, F L ; Gower, E ; Gschwantler, M ; Guimarães Pessôa, M ; Hindman, S J ; Hofer, H ; Husa, P ; Kåberg, M ; Kaita, K D E ; Kautz, A ; Kaymakoglu, S ; Krajden, M ; Krarup, H ; Laleman, W ; Lavanchy, D ; Marinho, R T ; Marotta, P ; Mauss, S ; Moreno, C ; Murphy, K ; Negro, F ; Nemecek, V ; Örmeci, N ; Øvrehus, A L H ; Parkes, J ; Pasini, K ; Peltekian, K M ; Ramji, A ; Reis, N ; Roberts, S K ; Rosenberg, W M ; Roudot-Thoraval, F ; Ryder, S D ; Sarmento-Castro, R ; Semela, D ; Sherman, M ; Shiha, G E ; Sievert, W ; Sperl, J ; Stärkel, P ; Stauber, R E ; Thompson, A J ; Urbanek, P ; Van Damme, P ; van Thiel, I ; Van Vlierberghe, H ; Vandijck, D ; Wedemeyer, H ; Weis, N ; Wiegand, J ; Yosry, A ; Zekry, A ; Cornberg, M ; Müllhaupt, B ; Estes, C. / The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm. I: Journal of Viral Hepatitis. 2014 ; Bind 21 Suppl 1. s. 34-59.

Bibtex

@article{d018d3e619aa479c9bac99e2a9511108,
title = "The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm",
abstract = "The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Antiviral Agents, Child, Child, Preschool, Drug Therapy, Combination, Female, Global Health, Hepatitis C, Chronic, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Models, Statistical, Prevalence, Young Adult",
author = "H Razavi and I Waked and C Sarrazin and Myers, {R P} and R Idilman and F Calinas and W Vogel and {Mendes Correa}, {M C} and C H{\'e}zode and P L{\'a}zaro and U Akarca and S Aleman and I Balık and T Berg and F Bihl and M Bilodeau and Blasco, {A J} and {Brand{\~a}o Mello}, {C E} and P Bruggmann and M Buti and Calleja, {J L} and H Cheinquer and Christensen, {P B} and M Clausen and Coelho, {H S M} and Cramp, {M E} and Dore, {G J} and W Doss and Duberg, {A S} and El-Sayed, {M H} and G Erg{\"o}r and G Esmat and K Falconer and J F{\'e}lix and Ferraz, {M L G} and Ferreira, {P R} and S Frankova and J Garc{\'i}a-Samaniego and J Gerstoft and Giria, {J A} and Gon{\cc}ales, {F L} and E Gower and M Gschwantler and {Guimar{\~a}es Pess{\^o}a}, M and Hindman, {S J} and H Hofer and P Husa and M K{\aa}berg and Kaita, {K D E} and A Kautz and S Kaymakoglu and M Krajden and H Krarup and W Laleman and D Lavanchy and Marinho, {R T} and P Marotta and S Mauss and C Moreno and K Murphy and F Negro and V Nemecek and N {\"O}rmeci and {\O}vrehus, {A L H} and J Parkes and K Pasini and Peltekian, {K M} and A Ramji and N Reis and Roberts, {S K} and Rosenberg, {W M} and F Roudot-Thoraval and Ryder, {S D} and R Sarmento-Castro and D Semela and M Sherman and Shiha, {G E} and W Sievert and J Sperl and P St{\"a}rkel and Stauber, {R E} and Thompson, {A J} and P Urbanek and {Van Damme}, P and {van Thiel}, I and {Van Vlierberghe}, H and D Vandijck and H Wedemeyer and N Weis and J Wiegand and A Yosry and A Zekry and M Cornberg and B M{\"u}llhaupt and C Estes",
note = "{\circledC} 2014 John Wiley & Sons Ltd.",
year = "2014",
month = "5",
doi = "10.1111/jvh.12248",
language = "English",
volume = "21 Suppl 1",
pages = "34--59",
journal = "Journal of Viral Hepatitis",
issn = "1352-0504",
publisher = "Wiley-Blackwell Publishing Ltd",

}

RIS

TY - JOUR

T1 - The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

AU - Razavi, H

AU - Waked, I

AU - Sarrazin, C

AU - Myers, R P

AU - Idilman, R

AU - Calinas, F

AU - Vogel, W

AU - Mendes Correa, M C

AU - Hézode, C

AU - Lázaro, P

AU - Akarca, U

AU - Aleman, S

AU - Balık, I

AU - Berg, T

AU - Bihl, F

AU - Bilodeau, M

AU - Blasco, A J

AU - Brandão Mello, C E

AU - Bruggmann, P

AU - Buti, M

AU - Calleja, J L

AU - Cheinquer, H

AU - Christensen, P B

AU - Clausen, M

AU - Coelho, H S M

AU - Cramp, M E

AU - Dore, G J

AU - Doss, W

AU - Duberg, A S

AU - El-Sayed, M H

AU - Ergör, G

AU - Esmat, G

AU - Falconer, K

AU - Félix, J

AU - Ferraz, M L G

AU - Ferreira, P R

AU - Frankova, S

AU - García-Samaniego, J

AU - Gerstoft, J

AU - Giria, J A

AU - Gonçales, F L

AU - Gower, E

AU - Gschwantler, M

AU - Guimarães Pessôa, M

AU - Hindman, S J

AU - Hofer, H

AU - Husa, P

AU - Kåberg, M

AU - Kaita, K D E

AU - Kautz, A

AU - Kaymakoglu, S

AU - Krajden, M

AU - Krarup, H

AU - Laleman, W

AU - Lavanchy, D

AU - Marinho, R T

AU - Marotta, P

AU - Mauss, S

AU - Moreno, C

AU - Murphy, K

AU - Negro, F

AU - Nemecek, V

AU - Örmeci, N

AU - Øvrehus, A L H

AU - Parkes, J

AU - Pasini, K

AU - Peltekian, K M

AU - Ramji, A

AU - Reis, N

AU - Roberts, S K

AU - Rosenberg, W M

AU - Roudot-Thoraval, F

AU - Ryder, S D

AU - Sarmento-Castro, R

AU - Semela, D

AU - Sherman, M

AU - Shiha, G E

AU - Sievert, W

AU - Sperl, J

AU - Stärkel, P

AU - Stauber, R E

AU - Thompson, A J

AU - Urbanek, P

AU - Van Damme, P

AU - van Thiel, I

AU - Van Vlierberghe, H

AU - Vandijck, D

AU - Wedemeyer, H

AU - Weis, N

AU - Wiegand, J

AU - Yosry, A

AU - Zekry, A

AU - Cornberg, M

AU - Müllhaupt, B

AU - Estes, C

N1 - © 2014 John Wiley & Sons Ltd.

PY - 2014/5

Y1 - 2014/5

N2 - The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.

AB - The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antiviral Agents

KW - Child

KW - Child, Preschool

KW - Drug Therapy, Combination

KW - Female

KW - Global Health

KW - Hepatitis C, Chronic

KW - Humans

KW - Incidence

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Middle Aged

KW - Models, Statistical

KW - Prevalence

KW - Young Adult

U2 - 10.1111/jvh.12248

DO - 10.1111/jvh.12248

M3 - Journal article

VL - 21 Suppl 1

SP - 34

EP - 59

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

SN - 1352-0504

ER -

ID: 45003996