Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

The impact of positive surgical margins on salvage radiation or androgen deprivation therapy following radical prostatectomy - a nationwide study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mortality from cardiovascular disease in women with breast cancer - a nationwide registry study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Impact of human papillomavirus in sinonasal cancer-a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Factors associated with melanoma-related limb lymphoedema

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Is the health literacy of informal caregivers associated with the psychological outcomes of breast cancer survivors?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of Depression After Radical Prostatectomy-A Nationwide Registry-based Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The extent to which positive surgical margins (PSM) affect the risk of subsequent salvage radiation therapy (sRT) or androgen depletion therapy (ADT) following radical prostatectomy (RP) is not well described. Initiation of additional therapies after RP depend on patient preference, individual factors, local guidelines, and life expectancy. The aim of this study was to analyze differences between margin status in risk of subsequent treatment for PCa following RP in a retrospective population-based cohort from Denmark.

METHODS: Patients who underwent RP were identified in The Danish Prostate Cancer Registry (DaPCaR). Subsequent sRT and ADT were assessed in uni- and multivariate settings and validated with receiver operating characteristic (ROC).

RESULTS: PSM was associated with an increased risk of sRT (HR = 1.85, p < .001) and receiving ADT (HR:1.39, p = .007). Margin status only had a minor impact on the predictive ability for sRT (area under the curve (AUC): p < .001) and no significant impact for subsequent ADT (AUC: p = 1). Significant inter-institutional difference in the association between PSM with sRT or ADT was observed.

CONCLUSION: PSM is associated with the risk of sRT and initiation of ADT, however this association is weak. Our results underline that factors beyond tumor characteristics play a major role for initiation of sRT and ADT.

OriginalsprogEngelsk
TidsskriftActa Oncologica
Vol/bind60
Udgave nummer5
Sider (fra-til)620-626
Antal sider7
ISSN0284-186X
DOI
StatusUdgivet - maj 2021

ID: 67022550