Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

The Feasibility of Implementing Deep Inspiration Breath-Hold for Pediatric Radiation Therapy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. ILROG Lymphoma Mini-Atlas Part II, Hodgkin Lymphoma

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  2. Diminishing Returns From Ultrahypofractionated Radiation Therapy for Prostate Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cardiac Lymphoma, a Challenging Extranodal Lymphoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Early-stage mantle cell lymphoma-a rare entity with special characteristics and needs for treatment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. ILROG Lymphoma Mini-Atlas Part II, Hodgkin Lymphoma

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

PURPOSE: Radiation therapy delivery during deep inspiration breath-hold (DIBH) reduces the irradiation of the heart and lungs and is therefore recommended for adults with mediastinal lymphoma. However, no studies have addressed the use of DIBH in children. This pilot study investigates the feasibility of and compliance with DIBH in children.

METHODS AND MATERIALS: Children from the age of 5 years were recruited to a training session to assess their ability to perform DIBH. No children received radiation therapy. The children were placed in a potential radiation therapy position. The DIBH was voluntary and monitored using an optical surface system providing visual feedback. Children who performed 3 stable DIBHs of 20 seconds each and remained motionless were deemed DIBH compliant. Compliance, equipment suitability, and coaching were further assessed in a semistructured interview.

RESULTS: We included 33 children (18 healthy and 15 hospitalized children with cancer) with a mean age of 8.5 years (range, 5-15). A total of 28 (85%) children were DIBH compliant. Twenty children were deemed immediately DIBH compliant, and 8 were deemed conditionally DIBH compliant, as DIBH compliance was presumed with custom-made immobilization and/or additional DIBH training. Mean age of the DIBH-compliant and the non-DIBH-compliant children was 8.9 years (range, 5-15) and 6 years (range, 5-9), respectively. Only 1 of 15 hospitalized children was not DIBH compliant and only 1 of all 33 children was unable to grasp the DIBH concept. The available DIBH equipment was suitable for children, and 94% reported that they were happy with training and performing DIBH.

CONCLUSIONS: This pilot study demonstrated that children from the age of 5 years can potentially comply with the DIBH technique and perform stable and reproducible DIBHs suitable for radiation therapy. Custom-made immobilization and adequate training will potentially increase DIBH compliance. A prospective clinical trial (NCT03315546), investigating the dosimetric benefit of radiation therapy delivery in DIBH compared with free breathing with pediatric patients, has been initiated.

OriginalsprogEngelsk
TidsskriftInternational Journal of Radiation Oncology Biology Physics
Vol/bind106
Udgave nummer5
Sider (fra-til)977-984
Antal sider8
ISSN0360-3016
DOI
StatusUdgivet - 1 apr. 2020

Bibliografisk note

Copyright © 2020 Elsevier Inc. All rights reserved.

ID: 61015995