Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
E-pub ahead of print

The effect of gestational age on major neurodevelopmental disorders in preterm infants

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. How to safeguard the brain of extremely preterm infants?

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Gestational age-dependent development of the neonatal metabolome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Changes in pulmonary oxygen content are detectable with laser absorption spectroscopy: proof of concept in newborn piglets

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Gut transit time, using radiological contrast imaging, to predict early signs of necrotizing enterocolitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. How to safeguard the brain of extremely preterm infants?

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Central data monitoring in the multicentre randomised SafeBoosC-III trial - a pragmatic approach

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The effect of early probiotic exposure on the preterm infant gut microbiome development

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Preterm infants have an increased risk of neurodevelopmental disorders. We established a direct quantitative comparison of the association between the degree of prematurity and three different neurodevelopmental disorders.

METHODS: In this cohort study, we combined data from 995,498 children in the Danish Medical Birth Register, from birth years 1997-2013, with information on cerebral palsy, epilepsy, and special educational needs. We estimated the gestational week-specific prevalence and risk for each of the disorders.

RESULTS: The risk ratio of cerebral palsy at gestational weeks 21-24, compared to term birth, was more than ten times higher than for the two other disorders. The prevalence of epilepsy and special educational needs declined almost parallel, with 9.2% (4.6%-13.5%) and 12.5% (11.2%-13.7%), respectively, per week of gestation toward term birth. Cerebral palsy did not decline similarly: from gestational weeks 21-24 until week 29 the prevalence declined insignificantly by 0.6% (-11.1%-11.0%) per week; whereas from week 29 until term, the prevalence declined markedly by 36.7% (25.9%-45.9%) per week.

CONCLUSIONS: The prevalence and risk of cerebral palsy are affected differently by the degree of prematurity compared with epilepsy and special educational needs, possibly reflecting important differences in cerebral pathophysiology.

IMPACT: For each week of gestation toward term birth, there was a clear log-linear decline in the prevalence of early childhood epilepsy and special educational needs. In contrast, the risk of cerebral palsy was high at the earliest gestational age, and the prevalence did not decline significantly until gestational week 29, from where it declined notably by nearly 40% for each week of gestation until term birth. Our results indicate important differences in the pathophysiological processes that associate preterm birth with these three neurodevelopmental disorders.

OriginalsprogEngelsk
TidsskriftPediatric Research
ISSN0031-3998
DOI
StatusE-pub ahead of print - 21 aug. 2021

ID: 67247314