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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

The density of knobs on Plasmodium falciparum-infected erythrocytes depends on developmental age and varies among isolates

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  1. Carotid plaque thickness is increased in chronic kidney disease and associated with carotid and coronary calcification

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  2. Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome

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  3. Lens fluorescence and skin fluorescence in the Copenhagen Twin Cohort Eye Study: Covariates and heritability

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  4. Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

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  1. Frequency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malaria

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Heart failure associated with imported malaria: a nationwide Danish cohort study

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  3. Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis

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  4. Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine

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Vis graf over relationer
The virulence of Plasmodium falciparum malaria is related to the parasite's ability to evade host immunity through clonal antigenic variation and tissue-specific adhesion of infected erythrocytes (IEs). The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family expressed on dome-shaped protrusions called knobs on the IE surface is central to both. Differences in receptor specificity and affinity of expressed PfEMP1 are important for IE adhesiveness, but it is not known whether differences in the number and size of the knobs on which the PfEMP1 proteins are expressed also play a role. Therefore, the aim of this study was to provide detailed information on isolate- and time-dependent differences in knob size and density.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind7
Udgave nummer9
Sider (fra-til)e45658
ISSN1932-6203
DOI
StatusUdgivet - 2012

ID: 36509610