Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association Between Long-Term Exposure to Wind Turbine Noise and the Risk of Stroke: Data From the Danish Nurse Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. GLP-1 is a coronary artery vasodilator in humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Inherited and environmental factors associated with sudden cardiac death. (PhD).

    Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  2. Subsequent Event Risk in Individuals With Established Coronary Heart Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A comprehensive evaluation of the genetic architecture of sudden cardiac arrest

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Exome data clouds the pathogenicity of genetic variants in Pulmonary Arterial Hypertension

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  5. Virus infection as a trigger for sudden cardiac arrest

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Michiel E Adriaens
  • Elisabeth M Lodder
  • Aida Moreno-Moral
  • Jan Šilhavý
  • Matthias Heinig
  • Charlotte Glinge
  • Charly Belterman
  • Rianne Wolswinkel
  • Enrico Petretto
  • Michal Pravenec
  • Carol Ann Remme
  • Connie R Bezzina
Vis graf over relationer

Background Electrocardiographic ( ECG ) parameters are regarded as intermediate phenotypes of cardiac arrhythmias. Insight into the genetic underpinnings of these parameters is expected to contribute to the understanding of cardiac arrhythmia mechanisms. Here we used HXB / BXH recombinant inbred rat strains to uncover genetic loci and candidate genes modulating ECG parameters. Methods and Results RR interval, PR interval, QRS duration, and QT c interval were measured from ECG s obtained in 6 male rats from each of the 29 available HXB / BXH recombinant inbred strains. Genes at loci displaying significant quantitative trait loci (QTL) effects were prioritized by assessing the presence of protein-altering variants, and by assessment of cis expression QTL ( eQTL ) effects and correlation of transcript abundance to the respective trait in the heart. Cardiac RNA -seq data were additionally used to generate gene co-expression networks. QTL analysis of ECG parameters identified 2 QTL for PR interval, respectively, on chromosomes 10 and 17. At the chromosome 10 QTL , cis- eQTL effects were identified for Acbd4, Cd300lg, Fam171a2, and Arhgap27; the transcript abundance in the heart of these 4 genes was correlated with PR interval. At the chromosome 17 QTL , a cis- eQTL was uncovered for Nhlrc1 candidate gene; the transcript abundance of this gene was also correlated with PR interval. Co-expression analysis furthermore identified 50 gene networks, 6 of which were correlated with PR interval or QRS duration, both parameters of cardiac conduction. Conclusions These newly identified genetic loci and gene networks associated with the ECG parameters of cardiac conduction provide a starting point for future studies with the potential of identifying novel mechanisms underlying cardiac electrical function.

OriginalsprogEngelsk
TidsskriftJournal of the American Heart Association
Vol/bind7
Udgave nummer21
Sider (fra-til)e009243
ISSN2047-9980
DOI
StatusUdgivet - 6 nov. 2018

ID: 56525573