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Rigshospitalet - en del af Københavns Universitetshospital
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Synthesis and in vitro evaluation of oxindole derivatives as potential radioligands for 5-HT(7) receptor imaging with PET

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DOI

  1. Development and Evaluation of Two Potential 5-HT7 Receptor PET Tracers: [18F]ENL09 and [18F]ENL10

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Development and Evaluation of Two Potential 5-HT7Receptor PET Tracers: [18F]ENL09 and [18F]ENL10

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Modulatory Role of Serotonin on Human Impulsive Aggression

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Structural brain abnormalities associated with cognitive impairments in bipolar disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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The most recently discovered serotonin (5-HT) receptor subtype, 5-HT(7), is considered to be associated with several CNS disorders. Noninvasive in vivo positron emission tomography (PET) studies of cerebral 5-HT(7) receptors could provide a significant advance in the understanding of the neurobiology and eventual dysfunctions of the 5-HT(7) receptor. To date, no appropriate 5-HT(7) receptor PET ligand has been developed. Here, we modified known 5-HT(7) selective phenylpiperazinyl-butyloxindole derivatives so that they may be labeled either with carbon-11 or fluorine-18. A set of potential 5-HT(7) ligands for PET molecular imaging was successfully synthesized. Two compounds (10 and 14) were tested against a range of targets. Both compounds display a promising in vitro profile with respect to PET imaging of the 5-HT(7) receptor in thalamic regions.
OriginalsprogEngelsk
TidsskriftA C S Chemical Neuroscience
Vol/bind3
Udgave nummer12
Sider (fra-til)1002-7
Antal sider6
ISSN1948-7193
DOI
StatusUdgivet - 2012

ID: 36809298