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Synchrotron radiation μCT and histology evaluation of bone-to-implant contact

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Author

Neldam, Camilla Albeck ; Sporring, Jon ; Rack, Alexander ; Lauridsen, Torsten ; Hauge, Ellen-Margrethe ; Jørgensen, Henrik L ; Jørgensen, Niklas Rye ; Feidenhansl, Robert ; Pinholt, Else Marie. / Synchrotron radiation μCT and histology evaluation of bone-to-implant contact. I: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 2017 ; Bind 45, Nr. 9. s. 1448-1457.

Bibtex

@article{c48831c1c8ad458f9af05583f1307d7e,
title = "Synchrotron radiation μCT and histology evaluation of bone-to-implant contact",
abstract = "The purpose of this study was to evaluate bone-to-implant contact (BIC) in two-dimensional (2D) histology compared to high-resolution three-dimensional (3D) synchrotron radiation micro computed tomography (SR micro-CT). High spatial resolution, excellent signal-to-noise ratio, and contrast establish SR micro-CT as the leading imaging modality for hard X-ray microtomography. Using SR micro-CT at voxel size 5 μm in an experimental goat mandible model, no statistically significant difference was found between the different treatment modalities nor between recipient and reconstructed bone. The histological evaluation showed a statistically significant difference between BIC in reconstructed and recipient bone (p < 0.0001). Further, no statistically significant difference was found between the different treatment modalities which we found was due to large variation and subsequently due to low power. Comparing histology and SR micro-CT evaluation a bias of 5.2{\%} was found in reconstructed area, and 15.3{\%} in recipient bone. We conclude that for evaluation of BIC with histology and SR micro-CT, SR micro-CT cannot be proven more precise than histology for evaluation of BIC, however, with this SR micro-CT method, one histologic bone section is comparable to the 3D evaluation. Further, the two methods complement each other with knowledge on BIC in 2D and 3D.",
keywords = "Journal Article",
author = "Neldam, {Camilla Albeck} and Jon Sporring and Alexander Rack and Torsten Lauridsen and Ellen-Margrethe Hauge and J{\o}rgensen, {Henrik L} and J{\o}rgensen, {Niklas Rye} and Robert Feidenhansl and Pinholt, {Else Marie}",
note = "Copyright {\circledC} 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.",
year = "2017",
month = "9",
doi = "10.1016/j.jcms.2017.05.019",
language = "English",
volume = "45",
pages = "1448--1457",
journal = "Journal of Cranio-Maxillofacial Surgery",
issn = "1010-5182",
publisher = "Churchill Livingstone",
number = "9",

}

RIS

TY - JOUR

T1 - Synchrotron radiation μCT and histology evaluation of bone-to-implant contact

AU - Neldam, Camilla Albeck

AU - Sporring, Jon

AU - Rack, Alexander

AU - Lauridsen, Torsten

AU - Hauge, Ellen-Margrethe

AU - Jørgensen, Henrik L

AU - Jørgensen, Niklas Rye

AU - Feidenhansl, Robert

AU - Pinholt, Else Marie

N1 - Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

PY - 2017/9

Y1 - 2017/9

N2 - The purpose of this study was to evaluate bone-to-implant contact (BIC) in two-dimensional (2D) histology compared to high-resolution three-dimensional (3D) synchrotron radiation micro computed tomography (SR micro-CT). High spatial resolution, excellent signal-to-noise ratio, and contrast establish SR micro-CT as the leading imaging modality for hard X-ray microtomography. Using SR micro-CT at voxel size 5 μm in an experimental goat mandible model, no statistically significant difference was found between the different treatment modalities nor between recipient and reconstructed bone. The histological evaluation showed a statistically significant difference between BIC in reconstructed and recipient bone (p < 0.0001). Further, no statistically significant difference was found between the different treatment modalities which we found was due to large variation and subsequently due to low power. Comparing histology and SR micro-CT evaluation a bias of 5.2% was found in reconstructed area, and 15.3% in recipient bone. We conclude that for evaluation of BIC with histology and SR micro-CT, SR micro-CT cannot be proven more precise than histology for evaluation of BIC, however, with this SR micro-CT method, one histologic bone section is comparable to the 3D evaluation. Further, the two methods complement each other with knowledge on BIC in 2D and 3D.

AB - The purpose of this study was to evaluate bone-to-implant contact (BIC) in two-dimensional (2D) histology compared to high-resolution three-dimensional (3D) synchrotron radiation micro computed tomography (SR micro-CT). High spatial resolution, excellent signal-to-noise ratio, and contrast establish SR micro-CT as the leading imaging modality for hard X-ray microtomography. Using SR micro-CT at voxel size 5 μm in an experimental goat mandible model, no statistically significant difference was found between the different treatment modalities nor between recipient and reconstructed bone. The histological evaluation showed a statistically significant difference between BIC in reconstructed and recipient bone (p < 0.0001). Further, no statistically significant difference was found between the different treatment modalities which we found was due to large variation and subsequently due to low power. Comparing histology and SR micro-CT evaluation a bias of 5.2% was found in reconstructed area, and 15.3% in recipient bone. We conclude that for evaluation of BIC with histology and SR micro-CT, SR micro-CT cannot be proven more precise than histology for evaluation of BIC, however, with this SR micro-CT method, one histologic bone section is comparable to the 3D evaluation. Further, the two methods complement each other with knowledge on BIC in 2D and 3D.

KW - Journal Article

U2 - 10.1016/j.jcms.2017.05.019

DO - 10.1016/j.jcms.2017.05.019

M3 - Journal article

VL - 45

SP - 1448

EP - 1457

JO - Journal of Cranio-Maxillofacial Surgery

JF - Journal of Cranio-Maxillofacial Surgery

SN - 1010-5182

IS - 9

ER -

ID: 52120490