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Rigshospitalet - en del af Københavns Universitetshospital
E-pub ahead of print

Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014: A nationwide study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Vis graf over relationer

BACKGROUND: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on the factors predicting long-term biochemical cure in MTC patients is non-existent on a population level. We conducted a nationwide retrospective cohort study of MTC in Denmark from 1997 to 2014, aiming to detect subgroups with survival similar to that of the general population and to identify prognostic factors for disease-specific survival and long-term biochemical cure.

METHODS: The study included 220 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. As a representative sample of the general population, we used a reference population matched fifty to one to the MTC cohort.

RESULTS: Patients diagnosed with hereditary MTC by screening (HR, 1.5; 95% CI, 0.5-4.3), patients without regional metastases (HR, 1.4; 95% CI, 0.9-2.3) and patients with stage I (HR, 1.3; 95% CI, 0.6-3.1), II (HR, 1.1; 95% CI, 0.6-2.3) and III (HR, 1.3; 95% CI, 0.4-4.2) disease had an overall survival similar to the reference population. On multivariate analysis, presence of distant metastases (HR, 12.3; 95% CI, 6.0-25.0) predicted worse disease-specific survival, while absence of regional lymph node metastases (OR, 40.1; 95% CI, 12.0-133.7) was the only independent prognostic factor for long-term biochemical cure.

CONCLUSION: Patients with hereditary MTC diagnosed by screening, patients without regional metastases and patients with stage I, II and III disease may have similar survival as the general population. Presence of distant metastases predicted worse disease-specific survival, while absence of regional metastases predicted long-term biochemical cure.

OriginalsprogEngelsk
TidsskriftThyroid : official journal of the American Thyroid Association
ISSN1050-7256
DOI
StatusE-pub ahead of print - 8 jan. 2019

ID: 56290354