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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Substantial molecular evolution and mutation rates in prolonged latent Mycobacterium tuberculosis infection in humans

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  • Troels Lillebaek
  • Anders Norman
  • Erik Michael Rasmussen
  • Rasmus L Marvig
  • Dorte Bek Folkvardsen
  • Åse Bengård Andersen
  • Lars Jelsbak
Vis graf over relationer

The genome of Mycobacterium tuberculosis (Mtb) of latently infected individuals may hold the key to understanding the processes that lead to reactivation and progression to clinical disease. We report here analysis of pairs of Mtb isolates from putative prolonged latent TB cases. We identified two confirmed cases, and used whole genome sequencing to investigate the mutational processes that occur over decades in latent Mtb. We found an estimated mutation rate between 0.2 and 0.3 over 33 years, suggesting that latent Mtb accumulates mutations at rates similar to observations from cases of active disease.

OriginalsprogEngelsk
TidsskriftInternational journal of medical microbiology : IJMM
Vol/bind306
Udgave nummer7
Sider (fra-til)580-585
Antal sider6
ISSN1438-4221
DOI
StatusUdgivet - nov. 2016

ID: 49201667