Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Subclinical hypothyroidism: A common finding in adult patients with cyanotic congenital heart disease

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Impact of feeding mode on neurodevelopmental outcome in infants and children with congenital heart disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Substance use, dental hygiene, and physical activity in adult patients with single ventricle physiology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Explanatory value of the ability index as assessed by cardiologists and patients with congenital heart disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. How do we define congenital heart defects for scientific studies?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cardiovascular complications in patients with total cavopulmonary connection: A nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Intravascular iliac artery lithotripsy to enable transfemoral thoracic endovascular aortic repair

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Feasibility and safety of transcaval transcatheter aortic valve implantation: a multicentre European registry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Impact of implant depth on hydrodynamic function of the ALLEGRA bioprosthesis in valve-in-valve interventions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Cyanotic congenital heart disease is a systemic disease, with effects on multiple organ systems. A high prevalence of subclinical hypothyroidism (SCH) has been reported in a small cohort of cyanotic congenital heart disease patients. Subclinical hypothyroidism has been associated with various adverse cardiovascular effects, as well as an increased risk of progression to overt hypothyroidism. The aim of this study was to examine the prevalence of SCH in cyanotic congenital heart disease patients, consider possible etiologies, and evaluate thyroid function over time.

METHODS: First, 90 clinically stable cyanotic congenital heart disease patients were examined with blood samples (thyroid-stimulating hormone, C-reactive protein, hemoglobin, hematocrit, and N-terminal pro-brain-natriuretic peptide) in a cross-sectional descriptive study. Second, a longitudinal follow-up study of 43 patients originating from the first study part, was carried out. These patients had thyroid function parameters (thyroid-stimulating hormone, thyroid hormones, and thyroid peroxidase antibodies) evaluated biannually.

RESULTS: Elevated thyroid-stimulating hormone was present in 24% of the 90 screened patients. During follow-up (6.5 ± 1.0 years), SCH (defined as ≥2 consecutive elevated thyroid-stimulating hormone values) was present in 26%. Three patients progressed to overt hypothyroidism. Patients with SCH were younger (34 ± 12 vs 42 ± 16 years; P = .01) and had a lower oxygen saturation (80 ± 5 vs 84 ± 6%; P = .03).

CONCLUSION: Subclinical hypothyroidism is a very common finding in cyanotic congenital heart disease. This is not associated with increased levels of C-reactive protein, heart failure, or autoimmunity but appears to be associated with cyanosis and age. Since the clinical impact of SCH is uncertain, further studies are needed to determine this. Regular thyroid evaluation is recommended in cyanotic congenital heart disease patients since SCH can develop to overt hypothyroidism.

OriginalsprogEngelsk
TidsskriftCongenital Heart Disease
Vol/bind13
Udgave nummer2
Sider (fra-til)263-270
ISSN1747-079X
DOI
StatusUdgivet - 2018

ID: 52217104