Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital

Structured clinical assessment of the ear, nose and throat in patients with granulomatosis with polyangiitis (Wegener's)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Diagnostic flexible pharyngo-laryngoscopy: development of a procedure specific assessment tool using a Delphi methodology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. European status on temporal bone training: a questionnaire study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Intraoperative Auditory System Monitoring

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Marcos Martinez Del Pero
  • Niels Rasmussen
  • Afzal Chaudhry
  • Piyush Jani
  • David Jayne
Vis graf over relationer
The objective of this prospective cross-sectional study is to describe the clinical otorhinolaryngological manifestations of granulomatosis with polyangiitis (Wegener's) (GPA) in a prospective cohort. All patients suffering from GPA seen in a tertiary centre between March 2007 and November 2008 had a detailed clinical assessment by an ENT surgeon of their ear, nose and head and neck complaints. An evaluation of whether there was disease activity and/or infection in each ENT area was made using the European Vasculitis Study Group guidelines. The number of patients assessed was 144. The proportion of female patients was 47 % (n = 69) and the median age was 57.7 years (IQ range 42.5-68.5). The prevalence of ENT involvement was 87 % (125/144). Hearing loss and abnormal tympanic membrane appearance were more common in patients with active disease and no infection (7/8 and 6/8, respectively, in active disease cf. 59/131 and 52/131, respectively, in remission). Nasal crusting was the most common nasal complaint recorded (52/144, 36 %) and bloody rhinorrhoea was the most common symptom in patients with disease activity. Rhinoscopy was highly sensitive in diagnosing disease activity (100 %). Subglottic stenosis was the most common head and neck manifestation (27/121, 22 %) and 74 % were symptomatic. In conclusion, the pattern and frequency of clinical ENT manifestations in GPA have been described in a large patient cohort. The use of tools readily available in the ENT clinic was essential to assess these patients accurately. This dataset will form the basis of an objective scoring system to measure disease activity in the ENT system.
TidsskriftEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Udgave nummer1
Sider (fra-til)345-54
Antal sider10
StatusUdgivet - jan. 2013

ID: 42572667