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Udgivet

Spinal Radiographic Progression and Predictors of Progression in Patients With Radiographic Axial Spondyloarthritis Receiving Ixekizumab Over 2 Years

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Test-retest Reliability for HAQ-DI and SF-36 PF for the Measurement of Physical Function in Psoriatic Arthritis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Désirée van der Heijde
  • Mikkel Østergaard
  • John D Reveille
  • Xenofon Baraliakos
  • Andris Kronbergs
  • David M Sandoval
  • Xiaoqi Li
  • Hilde Carlier
  • David H Adams
  • Walter P Maksymowych
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OBJECTIVE: To evaluate the long-term effect of ixekizumab (IXE) on radiographic changes in the spine in patients with radiographic axial spondyloarthritis (r-axSpA) by measuring change from baseline through 2 years in modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS), and to identify potential predictors of progression.

METHODS: This study evaluates patients from COAST-V (ClinicalTrials.gov: NCT02696785, biologic disease- modifying antirheumatic drug-naïve) and COAST-W (NCT02696798, tumor necrosis factor inhibitor- experienced) who had mSASSS data at baseline in the originating studies and 108 weeks after baseline in the extension study COAST-Y (NCT03129100). We examined the proportion of patients who did not have spinal radiographic progression through 2 years (108 weeks) of treatment with IXE (80 mg every 2 or 4 weeks) and the change from baseline to year 2 in mSASSS. Potential predictors of spinal radiographic progression were also evaluated.

RESULTS: Among patients with evaluable radiographs who were originally assigned to IXE (n = 230), mean (SD) change in mSASSS from baseline at year 2 was 0.3 (1.8). The proportion of nonprogressors over 2 years was 89.6% if defined as mSASSS change from baseline < 2 and 75.7% if defined as mSASSS change from baseline ≤ 0. Predictors of structural progression at year 2 (mSASSS change > 0) were age ≥ 40, baseline syndesmophytes, HLA-B27 positivity, and male sex. Week 52 inflammation in Spondyloarthritis Research Consortium of Canada spine was also a predictor of radiographic progression at year 2 in patients with magnetic resonance imaging data in COAST-V (n = 109).

CONCLUSION: The majority of patients with r-axSpA receiving IXE had no radiographic progression in the spine through 2 years of treatment. Predictors were generally consistent with previous studies.

OriginalsprogEngelsk
TidsskriftJournal of Rheumatology
Vol/bind49
Udgave nummer3
Sider (fra-til)265-273
Antal sider9
ISSN0315-162X
DOI
StatusUdgivet - mar. 2022

ID: 70404512