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E-pub ahead of print

Soluble markers of IL-1 activation as predictors of first-time smyocardial infarction in HIV-infected individuals

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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People with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to the general population. In a nested case-control study of 55 PWH with first-time Myocardial Infarction (MI) (cases) and 182 PWH with no CVD (controls), we measured soluble markers of IL-1 activation at 4 different timepoints before the case´s MI. Cases had higher levels of IL-1Ra at all time-points leading up to first-time MI, and higher levels of IL-1Ra were associated with approximately 1.5-fold increased risk of MI, supporting the rationale to target IL-1 activation in order to reduce cardiovascular risk in PWH.

OriginalsprogEngelsk
TidsskriftThe Journal of infectious diseases
ISSN0022-1899
DOI
StatusE-pub ahead of print - 11 maj 2019

Bibliografisk note

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

ID: 57149819