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Smoldering multiple myeloma risk factors for progression: a Danish population-based cohort study

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Sørrig, R, Klausen, TW, Salomo, M, Vangsted, AJ, Østergaard, B, Gregersen, H, Frølund, UC, Andersen, NF, Helleberg, C, Andersen, KT, Pedersen, RS, Pedersen, P, Abildgaard, N, Gimsing, P & Danish Myeloma Study Group 2015, 'Smoldering multiple myeloma risk factors for progression: a Danish population-based cohort study' European Journal of Haematology. https://doi.org/10.1111/ejh.12728

APA

CBE

Sørrig R, Klausen TW, Salomo M, Vangsted AJ, Østergaard B, Gregersen H, Frølund UC, Andersen NF, Helleberg C, Andersen KT, Pedersen RS, Pedersen P, Abildgaard N, Gimsing P, Danish Myeloma Study Group. 2015. Smoldering multiple myeloma risk factors for progression: a Danish population-based cohort study. European Journal of Haematology. https://doi.org/10.1111/ejh.12728

MLA

Vancouver

Author

Sørrig, Rasmus ; Klausen, Tobias W ; Salomo, Morten ; Vangsted, Annette J ; Østergaard, Brian ; Gregersen, Henrik ; Frølund, Ulf Christian ; Andersen, Niels F ; Helleberg, Carsten ; Andersen, Kristian T ; Pedersen, Robert S ; Pedersen, Per ; Abildgaard, Niels ; Gimsing, Peter ; Danish Myeloma Study Group. / Smoldering multiple myeloma risk factors for progression : a Danish population-based cohort study. I: European Journal of Haematology. 2015.

Bibtex

@article{7be51c9afc9945c89947bd5a698eb7f5,
title = "Smoldering multiple myeloma risk factors for progression: a Danish population-based cohort study",
abstract = "Several risk scores for disease progression in Smoldering Multiple Myeloma (SMM) patients have been proposed, however, all have been developed using single center registries. To examine risk factors for time to progression (TTP) to Multiple Myeloma (MM) for SMM we analyzed a nationwide population-based cohort of 321 newly diagnosed SMM patients registered within the Danish Multiple Myeloma Registry between 2005 and 2014. Significant univariable risk factors for TTP were selected for multivariable Cox regression analyses. We found that both an M-protein ≥ 30g/l and immunoparesis significantly influenced TTP (HR 2.7, 95{\%}CI(1.5;4.7), p=0.001, and HR 3.3, 95{\%}CI(1.4;7.8), p=0.002 respectively). High free light chain (FLC) ratio did not significantly influence TTP in our cohort. Therefore, our data do not support the recent IMWG proposal of identifying patients with FLC ratio above 100 as having ultra-high risk of transformation to MM. Using only immunoparesis and M-protein ≥ 30g/l, we created a scoring system to identify low, intermediate and high risk SMM. This first population-based study of SMM patients confirms that an M-protein ≥ 30g/l and immunoparesis remain important risk factors for progression to MM. This article is protected by copyright. All rights reserved.",
author = "Rasmus S{\o}rrig and Klausen, {Tobias W} and Morten Salomo and Vangsted, {Annette J} and Brian {\O}stergaard and Henrik Gregersen and Fr{\o}lund, {Ulf Christian} and Andersen, {Niels F} and Carsten Helleberg and Andersen, {Kristian T} and Pedersen, {Robert S} and Per Pedersen and Niels Abildgaard and Peter Gimsing and {Danish Myeloma Study Group}",
note = "This article is protected by copyright. All rights reserved.",
year = "2015",
month = "12",
day = "29",
doi = "10.1111/ejh.12728",
language = "English",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell Munksgaard",

}

RIS

TY - JOUR

T1 - Smoldering multiple myeloma risk factors for progression

T2 - a Danish population-based cohort study

AU - Sørrig, Rasmus

AU - Klausen, Tobias W

AU - Salomo, Morten

AU - Vangsted, Annette J

AU - Østergaard, Brian

AU - Gregersen, Henrik

AU - Frølund, Ulf Christian

AU - Andersen, Niels F

AU - Helleberg, Carsten

AU - Andersen, Kristian T

AU - Pedersen, Robert S

AU - Pedersen, Per

AU - Abildgaard, Niels

AU - Gimsing, Peter

AU - Danish Myeloma Study Group

N1 - This article is protected by copyright. All rights reserved.

PY - 2015/12/29

Y1 - 2015/12/29

N2 - Several risk scores for disease progression in Smoldering Multiple Myeloma (SMM) patients have been proposed, however, all have been developed using single center registries. To examine risk factors for time to progression (TTP) to Multiple Myeloma (MM) for SMM we analyzed a nationwide population-based cohort of 321 newly diagnosed SMM patients registered within the Danish Multiple Myeloma Registry between 2005 and 2014. Significant univariable risk factors for TTP were selected for multivariable Cox regression analyses. We found that both an M-protein ≥ 30g/l and immunoparesis significantly influenced TTP (HR 2.7, 95%CI(1.5;4.7), p=0.001, and HR 3.3, 95%CI(1.4;7.8), p=0.002 respectively). High free light chain (FLC) ratio did not significantly influence TTP in our cohort. Therefore, our data do not support the recent IMWG proposal of identifying patients with FLC ratio above 100 as having ultra-high risk of transformation to MM. Using only immunoparesis and M-protein ≥ 30g/l, we created a scoring system to identify low, intermediate and high risk SMM. This first population-based study of SMM patients confirms that an M-protein ≥ 30g/l and immunoparesis remain important risk factors for progression to MM. This article is protected by copyright. All rights reserved.

AB - Several risk scores for disease progression in Smoldering Multiple Myeloma (SMM) patients have been proposed, however, all have been developed using single center registries. To examine risk factors for time to progression (TTP) to Multiple Myeloma (MM) for SMM we analyzed a nationwide population-based cohort of 321 newly diagnosed SMM patients registered within the Danish Multiple Myeloma Registry between 2005 and 2014. Significant univariable risk factors for TTP were selected for multivariable Cox regression analyses. We found that both an M-protein ≥ 30g/l and immunoparesis significantly influenced TTP (HR 2.7, 95%CI(1.5;4.7), p=0.001, and HR 3.3, 95%CI(1.4;7.8), p=0.002 respectively). High free light chain (FLC) ratio did not significantly influence TTP in our cohort. Therefore, our data do not support the recent IMWG proposal of identifying patients with FLC ratio above 100 as having ultra-high risk of transformation to MM. Using only immunoparesis and M-protein ≥ 30g/l, we created a scoring system to identify low, intermediate and high risk SMM. This first population-based study of SMM patients confirms that an M-protein ≥ 30g/l and immunoparesis remain important risk factors for progression to MM. This article is protected by copyright. All rights reserved.

U2 - 10.1111/ejh.12728

DO - 10.1111/ejh.12728

M3 - Journal article

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

ER -

ID: 45968288