Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Serum Lactate and A Relative Change in Lactate as Predictors of Mortality in Patients with Cardiogenic Shock - Results from The Cardshock Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Acute Lung Injury in Critically Ill Patients: Actin-Scavenger Gelsolin Signals Prolonged Respiratory Failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Absences of Endothelial Microvesicle Changes in the Presence of the Endotheliopathy of Trauma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Lactate is a Prognostic Factor in Patients Admitted with Suspected ST-Elevation Myocardial Infarction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Transfusion Strategies are Associated with Epigenetic Changes Following Blunt Trauma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Regional variation in out-of-hospital cardiac arrest: incidence and survival - a nationwide study of regions in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Time in therapeutic range and risk of thromboembolism and bleeding in patients with a mechanical heart valve prosthesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Matias Greve Lindholm
  • Mari Hongisto
  • Johan Lassus
  • Jindrich Spinar
  • John Parissis
  • Marek Banaszewski
  • Jose Silva-Cardoso
  • Valentina Carubelli
  • diSomma Salvatore
  • Alessandro Sionis
  • Alexandre Mebazaa
  • Harjola Veli-Pekka
  • Lars Kober
Vis graf over relationer

INTRODUCTION: Cardiogenic shock complicating acute myocardial infarction has a very high mortality. Our present study focuses on serial measurement of lactate during admission due to cardiogenic shock and the prognostic effect of lactate and a relative change in lactate in patients after admission and the institution of intensive care treatment.

METHODS AND RESULTS: This is a secondary analysis of the CardShock study. Data on lactate at baseline were available on 217 of 219 patients.In the study population the median baseline lactate was 2.8 (min-max range, 0.5-23.1) mmol/L.At admission, lactate was predictive of 30-day mortality with an adjusted HR of 1.20 (95% CI 1.14-1.27) mmol/L. Within the first 24 hours of admission, baseline lactate remained predictive of 30-day mortality. Lactate at 6 hours had a HR of 1.14 (95% CI 1.06-1.24) and corresponding values at 12 and 24 hours had a HR of 1.10 (1.04-1.17), and of HR 1.19 (95% CI 1.07-1.32), respectively. A 50% reduction in lactate within 6 hours resulted in a HR of 0.82 (95% CI 0.72-0.94). Corresponding hazard ratios at 12 and 24 hours, were 0.87 (95% CI 0.76-0.98) and 0.74 (95% CI 0.60-0.91).

CONCLUSION: The main findings of the present study are that baseline lactate is a powerful predictor of 30-day mortality, lactate at 6, 12, and 24 hours after admission are predictors of 30-day mortality, and a relative change in lactate is a significant predictor of survival within the first 24 hours after instituting intensive care treatment adding information beyond the information from baseline values.

OriginalsprogEngelsk
TidsskriftShock
Vol/bind53
Udgave nummer1
Sider (fra-til)43-49
ISSN1073-2322
DOI
StatusUdgivet - 2019

ID: 58229827