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Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer

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Harvard

Schilling, C, Stoeckli, SJ, Haerle, SK, Broglie, MA, Huber, GF, Sorensen, JA, Bakholdt, V, Krogdahl, A, von Buchwald, C, Bilde, A, Sebbesen, LR, Odell, E, Gurney, B, O'Doherty, M, de Bree, R, Bloemena, E, Flach, GB, Villarreal, PM, Fresno Forcelledo, MF, Junquera Gutiérrez, LM, Amézaga, JA, Barbier, L, Santamaría-Zuazua, J, Moreira, A, Jacome, M, Vigili, MG, Rahimi, S, Tartaglione, G, Lawson, G, Nollevaux, M-C, Grandi, C, Donner, D, Bragantini, E, Dequanter, D, Lothaire, P, Poli, T, Silini, EM, Sesenna, E, Dolivet, G, Mastronicola, R, Leroux, A, Sassoon, I, Sloan, P & McGurk, M 2015, 'Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer' European journal of cancer (Oxford, England : 1990), bind 51, nr. 18, s. 2777-84. https://doi.org/10.1016/j.ejca.2015.08.023

APA

Schilling, C., Stoeckli, S. J., Haerle, S. K., Broglie, M. A., Huber, G. F., Sorensen, J. A., ... McGurk, M. (2015). Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer. European journal of cancer (Oxford, England : 1990), 51(18), 2777-84. https://doi.org/10.1016/j.ejca.2015.08.023

CBE

Schilling C, Stoeckli SJ, Haerle SK, Broglie MA, Huber GF, Sorensen JA, Bakholdt V, Krogdahl A, von Buchwald C, Bilde A, Sebbesen LR, Odell E, Gurney B, O'Doherty M, de Bree R, Bloemena E, Flach GB, Villarreal PM, Fresno Forcelledo MF, Junquera Gutiérrez LM, Amézaga JA, Barbier L, Santamaría-Zuazua J, Moreira A, Jacome M, Vigili MG, Rahimi S, Tartaglione G, Lawson G, Nollevaux M-C, Grandi C, Donner D, Bragantini E, Dequanter D, Lothaire P, Poli T, Silini EM, Sesenna E, Dolivet G, Mastronicola R, Leroux A, Sassoon I, Sloan P, McGurk M. 2015. Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer. European journal of cancer (Oxford, England : 1990). 51(18):2777-84. https://doi.org/10.1016/j.ejca.2015.08.023

MLA

Vancouver

Author

Schilling, Clare ; Stoeckli, Sandro J ; Haerle, Stephan K ; Broglie, Martina A ; Huber, Gerhard F ; Sorensen, Jens Ahm ; Bakholdt, Vivi ; Krogdahl, Annelise ; von Buchwald, Christian ; Bilde, Anders ; Sebbesen, Lars R ; Odell, Edward ; Gurney, Benjamin ; O'Doherty, Michael ; de Bree, Remco ; Bloemena, Elisabeth ; Flach, Geke B ; Villarreal, Pedro M ; Fresno Forcelledo, Manuel Florentino ; Junquera Gutiérrez, Luis Manuel ; Amézaga, Julio Alvarez ; Barbier, Luis ; Santamaría-Zuazua, Joseba ; Moreira, Augusto ; Jacome, Manuel ; Vigili, Maurizio Giovanni ; Rahimi, Siavash ; Tartaglione, Girolamo ; Lawson, Georges ; Nollevaux, Marie-Cecile ; Grandi, Cesare ; Donner, Davide ; Bragantini, Emma ; Dequanter, Didier ; Lothaire, Philippe ; Poli, Tito ; Silini, Enrico M ; Sesenna, Erinco ; Dolivet, Giles ; Mastronicola, Romina ; Leroux, Agnes ; Sassoon, Isabel ; Sloan, Philip ; McGurk, Mark. / Sentinel European Node Trial (SENT) : 3-year results of sentinel node biopsy in oral cancer. I: European journal of cancer (Oxford, England : 1990). 2015 ; Bind 51, Nr. 18. s. 2777-84.

Bibtex

@article{c1442617c01d4fa1a6e959273806499b,
title = "Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer",
abstract = "PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma.METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005. Fourteen European centres recruited 415 patients with radiologically staged T1-T2N0 squamous cell carcinoma. SNB was undertaken with an average of 3.2 nodes removed per patient. Patients were excluded if the sentinel node (SN) could not be identified. A positive SN led to a neck dissection within 3 weeks. Analysis was performed at 3-year follow-up.RESULTS: An SN was found in 99.5{\%} of cases. Positive SNs were found in 23{\%} (94 in 415). A false-negative result occurred in 14{\%} (15 in 109) of patients, of whom eight were subsequently rescued by salvage therapy. Recurrence after a positive SNB and subsequent neck dissection occurred in 22 patients, of which 16 (73{\%}) were in the neck and just six patients were rescued. Only minor complications (3{\%}) were reported following SNB. Disease-specific survival was 94{\%}. The sensitivity of SNB was 86{\%} and the negative predictive value 95{\%}.CONCLUSION: These data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer. EORTC Protocol 24021: Sentinel Node Biopsy in the Management of Oral and Oropharyngeal Squamous Cell Carcinoma.",
author = "Clare Schilling and Stoeckli, {Sandro J} and Haerle, {Stephan K} and Broglie, {Martina A} and Huber, {Gerhard F} and Sorensen, {Jens Ahm} and Vivi Bakholdt and Annelise Krogdahl and {von Buchwald}, Christian and Anders Bilde and Sebbesen, {Lars R} and Edward Odell and Benjamin Gurney and Michael O'Doherty and {de Bree}, Remco and Elisabeth Bloemena and Flach, {Geke B} and Villarreal, {Pedro M} and {Fresno Forcelledo}, {Manuel Florentino} and {Junquera Guti{\'e}rrez}, {Luis Manuel} and Am{\'e}zaga, {Julio Alvarez} and Luis Barbier and Joseba Santamar{\'i}a-Zuazua and Augusto Moreira and Manuel Jacome and Vigili, {Maurizio Giovanni} and Siavash Rahimi and Girolamo Tartaglione and Georges Lawson and Marie-Cecile Nollevaux and Cesare Grandi and Davide Donner and Emma Bragantini and Didier Dequanter and Philippe Lothaire and Tito Poli and Silini, {Enrico M} and Erinco Sesenna and Giles Dolivet and Romina Mastronicola and Agnes Leroux and Isabel Sassoon and Philip Sloan and Mark McGurk",
note = "Copyright {\circledC} 2015. Published by Elsevier Ltd.",
year = "2015",
month = "12",
doi = "10.1016/j.ejca.2015.08.023",
language = "English",
volume = "51",
pages = "2777--84",
journal = "European Journal of Cancer, Supplement",
issn = "0959-8049",
publisher = "Pergamon",
number = "18",

}

RIS

TY - JOUR

T1 - Sentinel European Node Trial (SENT)

T2 - 3-year results of sentinel node biopsy in oral cancer

AU - Schilling, Clare

AU - Stoeckli, Sandro J

AU - Haerle, Stephan K

AU - Broglie, Martina A

AU - Huber, Gerhard F

AU - Sorensen, Jens Ahm

AU - Bakholdt, Vivi

AU - Krogdahl, Annelise

AU - von Buchwald, Christian

AU - Bilde, Anders

AU - Sebbesen, Lars R

AU - Odell, Edward

AU - Gurney, Benjamin

AU - O'Doherty, Michael

AU - de Bree, Remco

AU - Bloemena, Elisabeth

AU - Flach, Geke B

AU - Villarreal, Pedro M

AU - Fresno Forcelledo, Manuel Florentino

AU - Junquera Gutiérrez, Luis Manuel

AU - Amézaga, Julio Alvarez

AU - Barbier, Luis

AU - Santamaría-Zuazua, Joseba

AU - Moreira, Augusto

AU - Jacome, Manuel

AU - Vigili, Maurizio Giovanni

AU - Rahimi, Siavash

AU - Tartaglione, Girolamo

AU - Lawson, Georges

AU - Nollevaux, Marie-Cecile

AU - Grandi, Cesare

AU - Donner, Davide

AU - Bragantini, Emma

AU - Dequanter, Didier

AU - Lothaire, Philippe

AU - Poli, Tito

AU - Silini, Enrico M

AU - Sesenna, Erinco

AU - Dolivet, Giles

AU - Mastronicola, Romina

AU - Leroux, Agnes

AU - Sassoon, Isabel

AU - Sloan, Philip

AU - McGurk, Mark

N1 - Copyright © 2015. Published by Elsevier Ltd.

PY - 2015/12

Y1 - 2015/12

N2 - PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma.METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005. Fourteen European centres recruited 415 patients with radiologically staged T1-T2N0 squamous cell carcinoma. SNB was undertaken with an average of 3.2 nodes removed per patient. Patients were excluded if the sentinel node (SN) could not be identified. A positive SN led to a neck dissection within 3 weeks. Analysis was performed at 3-year follow-up.RESULTS: An SN was found in 99.5% of cases. Positive SNs were found in 23% (94 in 415). A false-negative result occurred in 14% (15 in 109) of patients, of whom eight were subsequently rescued by salvage therapy. Recurrence after a positive SNB and subsequent neck dissection occurred in 22 patients, of which 16 (73%) were in the neck and just six patients were rescued. Only minor complications (3%) were reported following SNB. Disease-specific survival was 94%. The sensitivity of SNB was 86% and the negative predictive value 95%.CONCLUSION: These data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer. EORTC Protocol 24021: Sentinel Node Biopsy in the Management of Oral and Oropharyngeal Squamous Cell Carcinoma.

AB - PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma.METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005. Fourteen European centres recruited 415 patients with radiologically staged T1-T2N0 squamous cell carcinoma. SNB was undertaken with an average of 3.2 nodes removed per patient. Patients were excluded if the sentinel node (SN) could not be identified. A positive SN led to a neck dissection within 3 weeks. Analysis was performed at 3-year follow-up.RESULTS: An SN was found in 99.5% of cases. Positive SNs were found in 23% (94 in 415). A false-negative result occurred in 14% (15 in 109) of patients, of whom eight were subsequently rescued by salvage therapy. Recurrence after a positive SNB and subsequent neck dissection occurred in 22 patients, of which 16 (73%) were in the neck and just six patients were rescued. Only minor complications (3%) were reported following SNB. Disease-specific survival was 94%. The sensitivity of SNB was 86% and the negative predictive value 95%.CONCLUSION: These data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer. EORTC Protocol 24021: Sentinel Node Biopsy in the Management of Oral and Oropharyngeal Squamous Cell Carcinoma.

U2 - 10.1016/j.ejca.2015.08.023

DO - 10.1016/j.ejca.2015.08.023

M3 - Journal article

VL - 51

SP - 2777

EP - 2784

JO - European Journal of Cancer, Supplement

JF - European Journal of Cancer, Supplement

SN - 0959-8049

IS - 18

ER -

ID: 46001125