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Self-reported limitations in physical function are common 6 months after out-of-hospital cardiac arrest

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Katarina Heimburg
  • Tobias Cronberg
  • Åsa B. Tornberg
  • Susann Ullén
  • Hans Friberg
  • Niklas Nielsen
  • Christian Hassager
  • Janneke Horn
  • Jesper Kjærgaard
  • Michael Kuiper
  • Christian Rylander
  • Matt P. Wise
  • Gisela Lilja
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Title: Self-reported limitations in physical function are common 6 months after out-of-hospital cardiac arrest.

Background: Out-of-hospital cardiac arrest (OHCA) survivors generally report good health-related quality of life, but physical aspects of health seem more affected than other domains. Limitations in physical function after surviving OHCA have received little attention.

Aims: To describe physical function 6 months after OHCA and compare it with a group of ST elevation myocardial infarction (STEMI) controls, matched for country, age, sex and time of the cardiac event. A second aim was to explore variables potentially associated with self-reported limitations in physical function in OHCA survivors.

Methods: A cross-sectional sub-study of the Targeted Temperature Management at 33 °C versus 36 °C (TTM) trial with a follow-up 6 months post-event. Physical function was the main outcome assessed with the self-reported Physical Functioning-10 items scale (PF-10). PF-10 is presented as T-scores (0-100), where 50 represents the norm mean. Scores <47 at a group level, or <45 at an individual level indicate limitations in physical function.

Results: 287 OHCA survivors and 119 STEMI controls participated. Self-reported physical function by PF-10 was significantly lower for OHCA survivors compared to STEMI controls (mean 46.0, SD 11.2 vs. 48.8, SD 9.0, p = 0.025). 38% of OHCA survivors compared to 26% of STEMI controls reported limitations in physical function at an individual level (p = 0.022). The most predictive variables for self-reported limitations in physical function in OHCA survivors were older age, female sex, cognitive impairment, and symptoms of anxiety and depression after 6 months.

Conclusion: Self-reported limitations in physical function are more common in OHCA survivors compared to STEMI controls.

Trial registration: Identifier: NCT01946932.

TidsskriftResuscitation plus
StatusUdgivet - sep. 2022

Bibliografisk note

Funding Information:
This work is supported by grants from The Skane University Hospital Foundations 2019-o000032, 2019; The Skane University Hospital Vårdakademin 2018; Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research 2019 and the Gyllenstierna-Krapperup Foundation 2016-0051, 2016. The study sponsors have no involvement in the study design, in the collection of data, or in the forthcoming analyses and interpretation of data, writings of manuscript of manuscripts or in the decisions to submit manuscripts for publication.

Publisher Copyright:
© 2022 The Author(s)

ID: 80260109