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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Self-reported diseases and symptoms by rupture status among unselected Danish women with cosmetic silicone breast implants

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  • Lisbet R Hölmich
  • Kim Kjøller
  • Jon P Fryzek
  • Mimi Høier-Madsen
  • Ilse Vejborg
  • Carsten Conrad
  • Susanne Sletting
  • Joseph K McLaughlin
  • Vibeke Breiting
  • Søren Friis
Vis graf over relationer

Epidemiologic evidence does not support an association between silicone breast implants and connective tissue or other rheumatic diseases. However, a recent study has suggested that women with ruptured implants may be at increased risk of developing fibromyalgia. An analysis of adverse health outcomes according to breast implant rupture status was conducted in 238 unselected Danish women with cosmetic silicone breast implants. Ninety-two of the women had definite implant rupture, and 146 had intact implants as determined by magnetic resonance imaging. Before undergoing imaging, the women provided blood samples and completed a self-administered questionnaire. Women with ruptured implants overall, and the subgroup with extracapsular ruptures (n = 23), were compared with women with intact implants regarding a number of self-reported diseases and symptoms and the presence of specific autoantibodies, such as antinuclear antibodies, rheumatoid factor, and cardiolipin immunoglobulin G and M antibodies. Overall, there were no differences in the occurrence of self-reported diseases or symptoms or in the presence of autoantibodies between women with intact implants and women with ruptured implants, including extracapsular rupture. The only exception was capsular contracture, which was reported six times more frequently by women with extracapsular ruptures than by women with intact implants (OR, 6.3; 95 percent CI, 1.7 to 23.5). In conclusion, this study of unselected women with silicone breast implants could establish no association between silicone implant rupture and specific diseases or symptoms related to connective tissue disease or other rheumatic conditions, except for an excess of capsular contracture among women with extracapsular rupture.

OriginalsprogEngelsk
TidsskriftPlastic and Reconstructive Surgery
Vol/bind111
Udgave nummer2
Sider (fra-til)723-32; discussion 733-4
ISSN0032-1052
DOI
StatusUdgivet - feb. 2003

ID: 56444586