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Rigshospitalet - en del af Københavns Universitetshospital
E-pub ahead of print

Risk of new malignancies among patients with CLL treated with chemotherapy: results of a Danish population-based study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Abnormal eosinophil count at CLL diagnosis correlates with shorter treatment free survival

    Publikation: Bidrag til tidsskriftLetterpeer review

  4. Protein phosphatase, Mg2+/Mn2+-dependent 1D (PPM1D) mutations in haematological cancer

    Publikation: Bidrag til tidsskriftReviewpeer review

Vis graf over relationer

Patients with chronic lymphocytic leukaemia (CLL) have an increased risk of new malignancies. However, limited data have been published about the impact of CLL treatment on this risk. Here we followed a Danish population-based cohort of CLL patients for risks of new malignancies. Patients in the Danish CLL registry (2008-2017) were included. Up to 50 CLL-free matched comparators were identified. First-line treatment was categorized into four groups; bendamustine, chlorambucil, fludarabine or other. Patients were followed from CLL diagnosis for individual types of malignancy. Adjusted hazard ratios (HR) for new malignancies and 95% confidence intervals (95% CI) were calculated. Overall, 4286 CLL patients and 214 150 controls developed 594 and 20 565 new malignancies respectively. Risk of new malignancies was increased for CLL patients. Chemotherapy treatment was registered for 1064 (25%) patients with CLL. Chemotherapy was associated with increased HR (1·51, 95% CI: 1·3-1·8) of any new malignancy. Specifically, fludarabine was associated with an increased risk of myelodysplastic syndrome (MDS) (HR 4·93, 95% CI: 1·2-19·8). Patients with CLL are at increased risk of other haematological and solid malignancies compared to the general population. Chemotherapy exposure is associated with increased risk of second malignancies and fludarabine is associated with increased risk of MDS.

OriginalsprogEngelsk
TidsskriftBritish Journal of Haematology
ISSN0007-1048
DOI
StatusE-pub ahead of print - 11 feb. 2021

Bibliografisk note

© 2021 British Society for Haematology and John Wiley & Sons Ltd.

ID: 62113273