Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Risk of endometrial cancer among women with benign ovarian tumors - A Danish nationwide cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Incidence of vulvar high-grade precancerous lesions and cancer in Denmark before and after introduction of HPV vaccination

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Non-epithelial ovarian cancer in Denmark - Incidence and survival over nearly 40 years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Human papillomavirus genotype-specific risks for cervical intraepithelial lesions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Borderline ovarian tumors in Denmark 1997-2018: Time trends in incidence by histology, age and educational level

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Low-dose aspirin use and risk of head and neck cancer-A Danish nationwide case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Endometrial cancer risk after fertility treatment: a population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • K Reinholdt
  • S K Kjaer
  • S Guleria
  • K Frederiksen
  • L Mellemkjær
  • C Munk
  • A Jensen
Vis graf over relationer

OBJECTIVE: The few studies on the association between benign ovarian tumors and endometrial cancer have been inconclusive. Using data from a large Danish register-based cohort study, we assessed the overall and type-specific risk of endometrial cancer among women with a benign ovarian tumor.

METHODS: We identified all Danish women diagnosed with a benign ovarian tumor during 1978-2016 in the Danish National Patient Register (n = 149,807). The study population was followed for subsequent development of endometrial cancer by linkage to the Danish Cancer Register and standardized incidence ratios (SIRs) with corresponding 95% confidence intervals (CIs) were calculated after correction for hysterectomy.

RESULTS: After a one-year delayed study entry, women with benign ovarian tumors had a decreased incidence of endometrial cancer (SIR = 0.74, 95% CI: 0.68-0.81) compared with women in the general Danish population. Both solid benign ovarian tumors (SIR = 0.79, 95% CI 0.70-0.88) and cystic benign ovarian tumors (SIR = 0.68, 95% CI 0.58-0.78) were associated with decreased incidences of endometrial cancer. Likewise, women with benign ovarian tumors had decreased incidences of both type I and type II endometrial cancer. The incidence of endometrial cancer was decreased to virtually the same magnitude irrespective of the age at diagnosis of a benign ovarian tumor and the reduction persisted throughout the follow-up period.

CONCLUSIONS: The risk of endometrial cancer was decreased beyond the first year after a benign ovarian tumor and the decrease persisted for 20 or more years. The possible underlying mechanisms are not known and should be investigated further.

OriginalsprogEngelsk
TidsskriftGynecologic Oncology
Vol/bind157
Udgave nummer2
Sider (fra-til)549-554
Antal sider6
ISSN0090-8258
DOI
StatusUdgivet - maj 2020

Bibliografisk note

Copyright © 2020 Elsevier Inc. All rights reserved.

ID: 61558059