Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Risk of cervical intraepithelial neoplasia grade 2 or worse after conization in relation to HPV vaccination status

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Common gene variants within 3'-untranslated regions as modulators of multiple myeloma risk and survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Gastrointestinal toxicity during induction treatment for childhood acute lymphoblastic leukemia: The impact of the gut microbiota

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of specific types of ovarian cancer after borderline ovarian tumors in Denmark: A nationwide study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Risk of anal high-grade squamous intraepithelial lesions among renal transplant recipients compared with immunocompetent controls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Human papillomavirus genotype-specific risks for cervical intraepithelial lesions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Human papillomavirus (HPV) is essential for developing cervical cancer and precancerous lesions. Currently, three vaccines are available, which are effective as prophylaxis against HPV infection, however, limited knowledge exists about the possible effect of vaccinating women treated with conization to prevent recurrence. The aim of our study was to examine the risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) after conization according to HPV vaccination status. Using Danish nationwide registries, we identified women diagnosed with CIN3 on the cone (2006-2012) and their HPV vaccination status. Vaccinees were defined as women vaccinated between 3 months before until 1 year after conization. The women were followed from 1 year after conization until diagnosis of CIN2+, conization, death, emigration or end of follow-up. Cox proportional hazard regression was used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of CIN2+ comparing vaccinees with nonvaccinees. The HR was adjusted for age, histology on cone, education, year of conization, repeat conizations and CIN2+ lesions between conization and start of follow-up. Altogether 17,128 women were included (2,074 vaccinees). There was a statistically nonsignificant lower risk of CIN2+ among vaccinees (HRadjusted = 0.86, 95% CI: 0.67-1.09). Women vaccinated 0-3 months before tended to have a slightly lower HR of CIN2+ (HRadjusted = 0.77, 95% CI: 0.45-1.32) than women vaccinated 0-12 months after conization (HRadjusted = 0.88, 95% CI: 0.67-1.14), although not statistically significantly different. Our results add to the current knowledge about the potential clinical effect of vaccination as an adjunct to conization of high-grade cervical neoplasia to decrease risk of recurrence.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind147
Udgave nummer3
Sider (fra-til)641-647
Antal sider7
ISSN0020-7136
DOI
StatusUdgivet - 1 aug. 2020

Bibliografisk note

© 2019 UICC.

ID: 58436719