Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Richter's transformation (RT) refers to the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Approximately, 2-10% of patients with CLL develop RT, most often as diffuse large B-cell lymphoma. To assess the incidence of RT, we examined risk factors for RT and death among patients with RT in a nationwide CLL cohort (from 2008 to 2016). Among 3772 patients, 113 had biopsy-proven RT. With a median follow-up of 4.3 years, the 5-year cumulative incidence of RT was 2.8%. Advanced Binet stage (B/C) (p<.001), unmutated IGHV (p<.001), and del(17p) (p<.001) were independently associated with risk of developing RT. Half of the patients with RT (49%) were treatment-naïve prior to transformation and demonstrated longer survival after RT compared to patients previously treated for CLL (6.1 vs. 2.8 years, p=.03). Whether this finding could be explained by a higher proportion of clonally unrelated RT among treatment-naïve patients, remain to be addressed.
Originalsprog | Engelsk |
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Tidsskrift | Leukemia and Lymphoma |
Vol/bind | 61 |
Udgave nummer | 6 |
Sider (fra-til) | 1435-1444 |
Antal sider | 10 |
ISSN | 1042-8194 |
DOI | |
Status | Udgivet - jun. 2020 |
ID: 60920959