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Reproductive history of the Danish multiple sclerosis population: A register-based study

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@article{39954318070e48f3894e9e436640f110,
title = "Reproductive history of the Danish multiple sclerosis population: A register-based study",
abstract = "BACKGROUND: A diagnosis of multiple sclerosis (MS) may impact the choice of parenthood.OBJECTIVE: To investigate the number of live births, abortions and ectopic pregnancies among persons with MS.METHODS: From the Danish Multiple Sclerosis Registry, we extracted data from all persons diagnosed with MS from 1960 to 1996 and matched each MS person with four reference persons. We used a negative binomial regression model for the live births and Poisson regression model for abortions and ectopic pregnancies. The total fertility rate (TFR) during 1960-2016 and the annual number of live births in the MS population were analysed.RESULTS: Persons with MS had fewer children than reference persons. Fewer women with MS had elective abortions after diagnosis (incidence rate ratio (IRR) = 0.88; 95% confidence interval (CI) = 0.78-1.00) than reference persons. There was no difference regarding the number of elective abortions, spontaneous abortions or ectopic pregnancies after onset. The TFR was lower for women with MS than for reference persons, and the number of annual live births by MS persons increased during 1960-2016.CONCLUSION: MS seems to considerably impact reproductive choices, especially after clinical diagnosis, resulting in the MS population having fewer children than the general population.",
author = "Moberg, {Julie Yoon} and Bjarne Laursen and Thygesen, {Lau Caspar} and Melinda Magyari",
year = "2020",
month = jul,
doi = "10.1177/1352458519851245",
language = "English",
volume = "26",
pages = "902--911",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "Sage Science Press (UK)",
number = "8",

}

RIS

TY - JOUR

T1 - Reproductive history of the Danish multiple sclerosis population

T2 - A register-based study

AU - Moberg, Julie Yoon

AU - Laursen, Bjarne

AU - Thygesen, Lau Caspar

AU - Magyari, Melinda

PY - 2020/7

Y1 - 2020/7

N2 - BACKGROUND: A diagnosis of multiple sclerosis (MS) may impact the choice of parenthood.OBJECTIVE: To investigate the number of live births, abortions and ectopic pregnancies among persons with MS.METHODS: From the Danish Multiple Sclerosis Registry, we extracted data from all persons diagnosed with MS from 1960 to 1996 and matched each MS person with four reference persons. We used a negative binomial regression model for the live births and Poisson regression model for abortions and ectopic pregnancies. The total fertility rate (TFR) during 1960-2016 and the annual number of live births in the MS population were analysed.RESULTS: Persons with MS had fewer children than reference persons. Fewer women with MS had elective abortions after diagnosis (incidence rate ratio (IRR) = 0.88; 95% confidence interval (CI) = 0.78-1.00) than reference persons. There was no difference regarding the number of elective abortions, spontaneous abortions or ectopic pregnancies after onset. The TFR was lower for women with MS than for reference persons, and the number of annual live births by MS persons increased during 1960-2016.CONCLUSION: MS seems to considerably impact reproductive choices, especially after clinical diagnosis, resulting in the MS population having fewer children than the general population.

AB - BACKGROUND: A diagnosis of multiple sclerosis (MS) may impact the choice of parenthood.OBJECTIVE: To investigate the number of live births, abortions and ectopic pregnancies among persons with MS.METHODS: From the Danish Multiple Sclerosis Registry, we extracted data from all persons diagnosed with MS from 1960 to 1996 and matched each MS person with four reference persons. We used a negative binomial regression model for the live births and Poisson regression model for abortions and ectopic pregnancies. The total fertility rate (TFR) during 1960-2016 and the annual number of live births in the MS population were analysed.RESULTS: Persons with MS had fewer children than reference persons. Fewer women with MS had elective abortions after diagnosis (incidence rate ratio (IRR) = 0.88; 95% confidence interval (CI) = 0.78-1.00) than reference persons. There was no difference regarding the number of elective abortions, spontaneous abortions or ectopic pregnancies after onset. The TFR was lower for women with MS than for reference persons, and the number of annual live births by MS persons increased during 1960-2016.CONCLUSION: MS seems to considerably impact reproductive choices, especially after clinical diagnosis, resulting in the MS population having fewer children than the general population.

U2 - 10.1177/1352458519851245

DO - 10.1177/1352458519851245

M3 - Journal article

C2 - 31144565

VL - 26

SP - 902

EP - 911

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 8

ER -

ID: 61517714