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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Relationship between patient presentation and morphology of coronary atherosclerosis by quantitative multidetector computed tomography

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Martina C de Knegt
  • Jesper J Linde
  • Andreas Fuchs
  • Michael H C Pham
  • Andreas K Jensen
  • Børge G Nordestgaard
  • Henning Kelbæk
  • Lars V Køber
  • Merete Heitmann
  • Gitte Fornitz
  • Jens D Hove
  • Klaus F Kofoed
  • CGPS, the CATCH, and the VERDICT Investigators
  • Rolf Steffensen (Medlem af forfattergruppering)
  • Birgit Jurlander (Medlem af forfattergruppering)
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AIMS: Quantitative computed tomography (QCT) allows assessment of morphological features of coronary atherosclerosis. We aimed to test the hypothesis that clinical patient presentation is associated with distinct morphological features of coronary atherosclerosis.

METHODS AND RESULTS: A total of 1652 participants, representing a spectrum of clinical risk profiles [787 asymptomatic individuals from the general population, 468 patients with acute chest pain without acute coronary syndrome (ACS), and 397 patients with acute chest pain and ACS], underwent multidetector computed tomography. Of these, 274 asymptomatic individuals, 254 patients with acute chest pain without ACS, and 327 patients with acute chest pain and ACS underwent QCT to assess coronary plaque volumes and proportions of dense calcium (DC), fibrous, fibro fatty (FF), and necrotic core (NC) tissue. Furthermore, the presence of vulnerable plaques, defined by plaque volume and tissue composition, was examined. Coronary plaque volume increased significantly with worsening clinical risk profile [geometric mean (95% confidence interval): 148 (129-166) mm3, 257 (224-295) mm3, and 407 (363-457) mm3, respectively, P < 0.001]. Plaque composition differed significantly across cohorts, P < 0.0001. The proportion of DC decreased, whereas FF and NC increased with worsening clinical risk profile (mean proportions DC: 33%, 23%, 23%; FF: 50%, 61%, 57%; and NC: 17%, 17%, 20%, respectively). Significant differences in plaque composition persisted after multivariable adjustment for age, gender, body surface area, hypertension, statin use at baseline, diabetes, smoking, family history of ischaemic heart disease, total plaque volume, and tube voltage, P < 0.01.

CONCLUSION: Coronary atherosclerotic plaque volume and composition are strongly associated to clinical presentation.

OriginalsprogEngelsk
TidsskriftEuropean heart journal cardiovascular Imaging
Vol/bind20
Udgave nummer11
Sider (fra-til)1221-1230
Antal sider10
ISSN1525-2167
DOI
StatusUdgivet - 1 nov. 2019

Bibliografisk note

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.

ID: 58247918