Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Relation between invasive hemodynamics and measured glomerular filtration rate by 51Cr-EDTA clearance in advanced heart failure

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Validation of plasma thyroxine and triiodothyronine methods on the ADVIA Centaur® XP

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Phenylephrine increases near-infrared spectroscopy determined muscle oxygenation during head-up tilt in men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Pediatric reference intervals for general clinical chemistry components - merging of studies from Denmark and Sweden

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. High-sensitivity troponin I in persistent atrial fibrillation - relation to NT-proBNP and markers of inflammation and haemostasis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Age-related renal function decline in Fabry disease patients on enzyme replacement therapy: a longitudinal cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Duration of Heart Failure and Effect of Defibrillator Implantation in Patients With Nonischemic Systolic Heart Failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. 2019 EACTS Expert Consensus on long-term mechanical circulatory support

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Interplay of pump design elements and bleeding predilection-Mechanisms for a forward momentum

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

The interaction between hemodynamics and kidney function in heart failure (HF) is incompletely understood. We investigated the association between invasive hemodynamic parameters and measured glomerular filtration rate (mGFR) by plasma clearance of 51-chromium-labeled ethylenediamine tetra-acetic acid ( 51 Cr-EDTA) in patients with advanced HF and tested the hypothesis that patients with reduced mGFR have lower cardiac index (CI) and mean arterial pressure (MAP) as well as higher central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP). We retrospectively studied 242 patients (mean age 50 ± 13 years) referred for evaluation for heart transplantation or implantation of a left ventricular assist device with a left ventricular ejection fraction < 45% on optimal medical therapy, who underwent right heart catheterization (RHC) and measurement of 51 Cr-EDTA clearance. Mean mGFR was 63 ± 21 mL/min/1.73 m 2 , CI was 2.3 ± 0.7 L/min/m 2 , PCWP was 21 ± 9 mmHg, and CVP was 10.3 ± 5.2 mmHg. Univariate analysis demonstrated a significant correlation between mGFR and CI (r 2 = 0.030, p =.007) and CVP (r 2 = 0.017, p =.049) but not between mGFR and MAP or PCWP. In multivariate analyses, none of the hemodynamic variables remained significantly associated with mGFR. While CVP and CI were correlated with mGFR in univariate analysis the results of analyses adjusted for multiple covariates suggest that hemodynamics are only correlated to renal function in advanced HF to a modest degree challenging the hypothesis that renal dysfunction in HF mainly is a consequence of renal congestion.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical and Laboratory Investigation
Vol/bind79
Udgave nummer3
Sider (fra-til)194-201
Antal sider8
ISSN0036-5513
DOI
StatusUdgivet - 3 apr. 2019

ID: 57662299