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Udgivet

Reduced H3K27me3 expression in radiation-associated angiosarcoma of the breast

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DOI

  1. Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Autopsy after transcatheter aortic valve implantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Laryngeal precursor lesions: Interrater and intrarater reliability of histopathological assessment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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The diagnosis of radiation-associated angiosarcoma is challenging and there are overlapping clinicopathological features between radiation-associated benign, atypical and malignant vascular lesions. It has been shown convincingly, that the majority of radiation-associated angiosarcomas are characterised by amplification and subsequent overexpression of MYC in contrast to benign and atypical vascular lesions. Given the fact that epigenetic changes play an important role in carcinogenesis and loss of histone H3K27 trimethylation (H3K27me3) has been found in a number of malignant neoplasms including malignant peripheral nerve sheath tumours, especially when associated with previous radiotherapy, we evaluated the immunohistochemical reaction pattern for H3K27me3 in 49 vascular lesions and control cases: normal skin and benign vascular lesions not associated with previous radiotherapy, radiation-associated benign, atypical and malignant vascular lesions and angiosarcomas not associated with previous radiotherapy. We found loss of H3K27me3 expression in most cases of radiation-associated angiosarcomas, whereas endothelial cells in benign and atypical vascular lesions arising after previous radiotherapy stained positively for H3K27me3. The sporadic angiosarcomas stained inconsistently for H3K27me3. Loss of H3K27me3 is typically seen in radiation-associated angiosarcomas, representing an additional diagnostic tool and raises questions in regard to the carcinogenesis of malignant vascular neoplasms.

OriginalsprogEngelsk
TidsskriftVirchows Archiv : an international journal of pathology
Vol/bind472
Udgave nummer3
Sider (fra-til)361-68
ISSN0945-6317
DOI
StatusUdgivet - 2018

ID: 52601698