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Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study

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Harvard

Lassen, MCH, Skaarup, KG, Lind, JN, Alhakak, AS, Sengeløv, M, Nielsen, AB, Simonsen, JØ, Johansen, ND, Davidovski, FS, Christensen, J, Bundgaard, H, Hassager, C, Jabbari, R, Carlsen, J, Kirk, O, Lindholm, MG, Kristiansen, OP, Nielsen, OW, Ulrik, CS, Sivapalan, P, Gislason, G, Møgelvang, R, Jensen, GB, Schnohr, P, Søgaard, P, Solomon, SD, Iversen, K, Jensen, JUS, Schou, M & Biering-Sørensen, T 2021, 'Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study', European Journal of Heart Failure. https://doi.org/10.1002/ejhf.2347

APA

Lassen, M. C. H., Skaarup, K. G., Lind, J. N., Alhakak, A. S., Sengeløv, M., Nielsen, A. B., Simonsen, J. Ø., Johansen, N. D., Davidovski, F. S., Christensen, J., Bundgaard, H., Hassager, C., Jabbari, R., Carlsen, J., Kirk, O., Lindholm, M. G., Kristiansen, O. P., Nielsen, O. W., Ulrik, C. S., ... Biering-Sørensen, T. (2021). Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.2347

CBE

Lassen MCH, Skaarup KG, Lind JN, Alhakak AS, Sengeløv M, Nielsen AB, Simonsen JØ, Johansen ND, Davidovski FS, Christensen J, Bundgaard H, Hassager C, Jabbari R, Carlsen J, Kirk O, Lindholm MG, Kristiansen OP, Nielsen OW, Ulrik CS, Sivapalan P, Gislason G, Møgelvang R, Jensen GB, Schnohr P, Søgaard P, Solomon SD, Iversen K, Jensen JUS, Schou M, Biering-Sørensen T. 2021. Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.2347

MLA

Vancouver

Author

Lassen, Mats Christian Højbjerg ; Skaarup, Kristoffer Grundtvig ; Lind, Jannie Nørgaard ; Alhakak, Alia Saed ; Sengeløv, Morten ; Nielsen, Anne Bjerg ; Simonsen, Jakob Øystein ; Johansen, Niklas Dyrby ; Davidovski, Filip Søskov ; Christensen, Jacob ; Bundgaard, Henning ; Hassager, Christian ; Jabbari, Reza ; Carlsen, Jørn ; Kirk, Ole ; Lindholm, Matias Greve ; Kristiansen, Ole Peter ; Nielsen, Olav Wendelboe ; Ulrik, Charlotte Suppli ; Sivapalan, Pradeesh ; Gislason, Gunnar ; Møgelvang, Rasmus ; Jensen, Gorm Boje ; Schnohr, Peter ; Søgaard, Peter ; Solomon, Scott D ; Iversen, Kasper ; Jensen, Jens Ulrik Staehr ; Schou, Morten ; Biering-Sørensen, Tor. / Recovery of Cardiac Function Following COVID-19 - ECHOVID-19 : A Prospective Longitudinal Cohort Study. I: European Journal of Heart Failure. 2021.

Bibtex

@article{e80c34e98acf468196c8ed8df6240d2a,
title = "Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study",
abstract = "AIMS: The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.METHODS AND RESULTS: A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72-92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3-408.0) ng/L vs. 11.7 (5.7-24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.CONCLUSION: Acute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.",
keywords = "COVID-19, Follow-up, Recovery following COVID-19, Strain echocardiography",
author = "Lassen, {Mats Christian H{\o}jbjerg} and Skaarup, {Kristoffer Grundtvig} and Lind, {Jannie N{\o}rgaard} and Alhakak, {Alia Saed} and Morten Sengel{\o}v and Nielsen, {Anne Bjerg} and Simonsen, {Jakob {\O}ystein} and Johansen, {Niklas Dyrby} and Davidovski, {Filip S{\o}skov} and Jacob Christensen and Henning Bundgaard and Christian Hassager and Reza Jabbari and J{\o}rn Carlsen and Ole Kirk and Lindholm, {Matias Greve} and Kristiansen, {Ole Peter} and Nielsen, {Olav Wendelboe} and Ulrik, {Charlotte Suppli} and Pradeesh Sivapalan and Gunnar Gislason and Rasmus M{\o}gelvang and Jensen, {Gorm Boje} and Peter Schnohr and Peter S{\o}gaard and Solomon, {Scott D} and Kasper Iversen and Jensen, {Jens Ulrik Staehr} and Morten Schou and Tor Biering-S{\o}rensen",
note = "This article is protected by copyright. All rights reserved.",
year = "2021",
month = sep,
day = "12",
doi = "10.1002/ejhf.2347",
language = "English",
journal = "European Journal of Heart Failure",
issn = "1388-9842",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Recovery of Cardiac Function Following COVID-19 - ECHOVID-19

T2 - A Prospective Longitudinal Cohort Study

AU - Lassen, Mats Christian Højbjerg

AU - Skaarup, Kristoffer Grundtvig

AU - Lind, Jannie Nørgaard

AU - Alhakak, Alia Saed

AU - Sengeløv, Morten

AU - Nielsen, Anne Bjerg

AU - Simonsen, Jakob Øystein

AU - Johansen, Niklas Dyrby

AU - Davidovski, Filip Søskov

AU - Christensen, Jacob

AU - Bundgaard, Henning

AU - Hassager, Christian

AU - Jabbari, Reza

AU - Carlsen, Jørn

AU - Kirk, Ole

AU - Lindholm, Matias Greve

AU - Kristiansen, Ole Peter

AU - Nielsen, Olav Wendelboe

AU - Ulrik, Charlotte Suppli

AU - Sivapalan, Pradeesh

AU - Gislason, Gunnar

AU - Møgelvang, Rasmus

AU - Jensen, Gorm Boje

AU - Schnohr, Peter

AU - Søgaard, Peter

AU - Solomon, Scott D

AU - Iversen, Kasper

AU - Jensen, Jens Ulrik Staehr

AU - Schou, Morten

AU - Biering-Sørensen, Tor

N1 - This article is protected by copyright. All rights reserved.

PY - 2021/9/12

Y1 - 2021/9/12

N2 - AIMS: The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.METHODS AND RESULTS: A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72-92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3-408.0) ng/L vs. 11.7 (5.7-24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.CONCLUSION: Acute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.

AB - AIMS: The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.METHODS AND RESULTS: A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72-92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3-408.0) ng/L vs. 11.7 (5.7-24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.CONCLUSION: Acute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.

KW - COVID-19

KW - Follow-up

KW - Recovery following COVID-19

KW - Strain echocardiography

UR - http://www.scopus.com/inward/record.url?scp=85117115266&partnerID=8YFLogxK

U2 - 10.1002/ejhf.2347

DO - 10.1002/ejhf.2347

M3 - Journal article

C2 - 34514713

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

ER -

ID: 67612004