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Quantitative Measurements of Motor Function in Alzheimer's Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study

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@article{8c2b278738c641cf89819233f6086cf2,
title = "Quantitative Measurements of Motor Function in Alzheimer's Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study",
abstract = "BACKGROUND: This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB).METHODS: In this cross-sectional study, 49 patients with a diagnosis of AD (n = 17), FTD (n = 19), or DLB (n = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping.RESULTS: Our results revealed significantly higher Q-Motor values in pronation/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Q-Motor values detected significant differences between AD and HC, while clinical ratings did not.CONCLUSION: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.",
author = "{Jeppesen Kragh}, Frederikke and Marie Bruun and Esben Budtz-J{\o}rgensen and Hjermind, {Lena Elisabeth} and Robin Schubert and Ralf Reilmann and Nielsen, {J{\o}rgen Erik} and Hasselbalch, {Steen Gregers}",
note = "{\textcopyright} 2018 S. Karger AG, Basel.",
year = "2018",
month = sep,
day = "26",
doi = "10.1159/000492860",
language = "English",
volume = "46",
pages = "168--179",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "S./Karger AG",
number = "3-4",

}

RIS

TY - JOUR

T1 - Quantitative Measurements of Motor Function in Alzheimer's Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies

T2 - A Proof-of-Concept Study

AU - Jeppesen Kragh, Frederikke

AU - Bruun, Marie

AU - Budtz-Jørgensen, Esben

AU - Hjermind, Lena Elisabeth

AU - Schubert, Robin

AU - Reilmann, Ralf

AU - Nielsen, Jørgen Erik

AU - Hasselbalch, Steen Gregers

N1 - © 2018 S. Karger AG, Basel.

PY - 2018/9/26

Y1 - 2018/9/26

N2 - BACKGROUND: This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB).METHODS: In this cross-sectional study, 49 patients with a diagnosis of AD (n = 17), FTD (n = 19), or DLB (n = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping.RESULTS: Our results revealed significantly higher Q-Motor values in pronation/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Q-Motor values detected significant differences between AD and HC, while clinical ratings did not.CONCLUSION: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.

AB - BACKGROUND: This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB).METHODS: In this cross-sectional study, 49 patients with a diagnosis of AD (n = 17), FTD (n = 19), or DLB (n = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping.RESULTS: Our results revealed significantly higher Q-Motor values in pronation/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Q-Motor values detected significant differences between AD and HC, while clinical ratings did not.CONCLUSION: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.

U2 - 10.1159/000492860

DO - 10.1159/000492860

M3 - Journal article

C2 - 30257254

VL - 46

SP - 168

EP - 179

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 3-4

ER -

ID: 55493159