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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Psoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Maria Ekelund
  • Kristiina Aalto
  • Anders Fasth
  • Troels Herlin
  • Susan Nielsen
  • Ellen Nordal
  • Suvi Peltoniemi
  • Marite Rygg
  • Marek Zak
  • Lillemor Berntson
  • Nordic Study Group of Pediatric Rheumatology (NoSPeR)
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BACKGROUND: To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA).

METHODS: In all, 440 children with JIA were followed for a median of 8 years in a prospective Nordic population-based cohort study. Data for remission was available for 427 of these children. The presence of psoriasis, psoriasis-like rash, dactylitis, nail pitting, enthesitis, tenosynovitis and heredity was assessed in relation to ILAR classification and remission.

RESULTS: Clinical findings associated with psoriasis developed consecutively during the 8-year period. Six of 14 children with psoriasis were not classified as juvenile psoriatic arthritis according to the ILAR criteria at 8 year follow-up. Dactylitis was more common in children with early onset of JIA. After 8 years we found a cumulative median number of eleven arthritic joints in children with psoriasis or psoriasis-like rash compared with six in the rest of the cohort (p = 0.02). Also, the chance for not being in remission after 8 years increased significantly in patients with psoriasis, psoriasis-like rash or at least two of: 1) first-degree heredity for psoriasis or psoriatic arthritis, 2) dactylitis or 3) nail pitting, compared with the rest of the group (OR 3.32, p = 0.010).

CONCLUSIONS: Our results indicate a more severe disease over time in psoriasis-associated JIA, as features of psoriasis develop during the disease course. This group is a major challenge to encompass in a future JIA classification in order to facilitate early tailored treatment.

OriginalsprogEngelsk
TidsskriftPediatric Rheumatology
Vol/bind15
Udgave nummer1
Sider (fra-til)13
ISSN1546-0096
DOI
StatusUdgivet - 22 feb. 2017

ID: 52170760