Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Prevalence of heart failure and other risk factors among first-degree relatives of women with peripartum cardiomyopathy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Clinical implications of electrocardiographic bundle branch block in primary care

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Syncope and orthostatic hypotension: early markers of cardiac disease in the general population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Heritability of resting heart rate and association with mortality in middle-aged and elderly twins

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. "Risk of de novo or secondary cancer after solid organ or allogeneic haematopoietic stem cell transplantation"

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effect of motivational interviewing on gestational weight gain and fetal growth in pregnant women with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. White coat hypertension in early pregnancy in women with pre-existing diabetes: prevalence and pregnancy outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVES: Peripartum cardiomyopathy (PPCM) is a rare disease carrying a risk of death and chronic heart failure.It is unknown if women with PPCM have a family history of heart failure. We investigated the prevalence of heart failure and hypertension in first-degree relatives to women with PPCM.

METHODS: A cohort of 61 women with PPCM was identified through the nationwide Danish registers from 2005 to 2014, and each individual diagnosis of PPCM was validated through review of patient records. We excluded 13 women due to lack of data on relatives. In a case-control design, the 48 remaining women were matched (on age, year of childbirth, parity and number of siblings) to 477 birth-giving Danish women without heart failure. We obtained information on first-degree relatives (parents and siblings) through the National Danish Registers.

RESULTS: The cohort of 48 women with PPCM had a mean age of 31 years (SD 6). The prevalence of heart failure in any first-degree relative was higher in women with PPCM, compared with controls (23% vs 10%, p=0.011). A first-degree relative with any cardiovascular diagnosis was not more frequent in women with PPCM versus controls (77% vs 70%, p=0.280), but for siblings only, any cardiovascular diagnosis was more frequent in siblings to women with PPCM (29% vs 16%, p=0.026).

CONCLUSION: Having a first-degree relative with heart failure was significantly more frequent in a cohort of validated PPCM cases than in controls, supporting the notion of shared aetiology between PPCM and other forms of heart failure.

OriginalsprogEngelsk
TidsskriftHeart (British Cardiac Society)
Vol/bind105
Udgave nummer14
Sider (fra-til)1057-1062
Antal sider6
ISSN1355-6037
DOI
StatusUdgivet - 1 jul. 2019

Bibliografisk note

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 57664342