Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{3ff41d9055a84f4e80b296f6f8a4a234,
title = "Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors",
abstract = "PURPOSE: This study sought to investigate the prevalence of self-reported cognitive impairment and its relation to illness and treatment characteristics and mental health in Hodgkin lymphoma (HL) and diffuse large B cell lymphoma (DLBCL) survivors as cancer-related cognitive impairment has not been extensively studied in lymphoma survivors.METHODS: One hundred fifteen HL and DLBCL survivors (mean age = 40.3 years, mean months since completed treatment = 29.6) completed questionnaires on executive function and mental health. We examined the prevalence of executive impairment and compared illness and treatment characteristics and mental health across survivors reporting impaired and non-impaired executive functioning using chi-square, Cochran-Armitage, and Mann-Whitney U tests.RESULTS: We found that 39% reported executive impairment. Survivors reporting impaired executive functioning reported worse mental health (ps < .001) than survivors reporting non-impaired executive functioning. A larger proportion of the impaired group had received a high chemo dose compared to the non-impaired group although this result fell short of significance after adjustment for multiple comparisons (p = .017).CONCLUSIONS: Self-reported cognitive impairment is prevalent in HL and DLBCL survivors and is associated with worse mental health and possibly high chemo dose. Future studies should investigate objective impairment and the possible dose-response relationship between chemo dose and cognitive impairment in lymphoma survivors.",
keywords = "Cancer-related cognitive impairment, Hodgkin lymphoma, Diffuse large B cell lymphoma, Self-reported cognitive function, Mental health, Hodgkin Disease/complications, Cognitive Dysfunction/etiology, Cancer Survivors, Prevalence, Humans, Middle Aged, Male, Young Adult, Denmark, Adult, Female, Executive Function/physiology, Mental Health/standards",
author = "Johanna Mariegaard and Jonathan Wenstrup and Lim, {Kevin Zi Ming} and Bidstrup, {Pernille Envold} and {von Heymann}, Annika and Christoffer Johansen and Knudsen, {Gitte Moos} and Ian Law and Lena Specht and Stenb{\ae}k, {Dea Siggaard}",
year = "2021",
month = jun,
doi = "10.1007/s00520-020-05857-4",
language = "English",
volume = "29",
pages = "3319--3328",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors

AU - Mariegaard, Johanna

AU - Wenstrup, Jonathan

AU - Lim, Kevin Zi Ming

AU - Bidstrup, Pernille Envold

AU - von Heymann, Annika

AU - Johansen, Christoffer

AU - Knudsen, Gitte Moos

AU - Law, Ian

AU - Specht, Lena

AU - Stenbæk, Dea Siggaard

PY - 2021/6

Y1 - 2021/6

N2 - PURPOSE: This study sought to investigate the prevalence of self-reported cognitive impairment and its relation to illness and treatment characteristics and mental health in Hodgkin lymphoma (HL) and diffuse large B cell lymphoma (DLBCL) survivors as cancer-related cognitive impairment has not been extensively studied in lymphoma survivors.METHODS: One hundred fifteen HL and DLBCL survivors (mean age = 40.3 years, mean months since completed treatment = 29.6) completed questionnaires on executive function and mental health. We examined the prevalence of executive impairment and compared illness and treatment characteristics and mental health across survivors reporting impaired and non-impaired executive functioning using chi-square, Cochran-Armitage, and Mann-Whitney U tests.RESULTS: We found that 39% reported executive impairment. Survivors reporting impaired executive functioning reported worse mental health (ps < .001) than survivors reporting non-impaired executive functioning. A larger proportion of the impaired group had received a high chemo dose compared to the non-impaired group although this result fell short of significance after adjustment for multiple comparisons (p = .017).CONCLUSIONS: Self-reported cognitive impairment is prevalent in HL and DLBCL survivors and is associated with worse mental health and possibly high chemo dose. Future studies should investigate objective impairment and the possible dose-response relationship between chemo dose and cognitive impairment in lymphoma survivors.

AB - PURPOSE: This study sought to investigate the prevalence of self-reported cognitive impairment and its relation to illness and treatment characteristics and mental health in Hodgkin lymphoma (HL) and diffuse large B cell lymphoma (DLBCL) survivors as cancer-related cognitive impairment has not been extensively studied in lymphoma survivors.METHODS: One hundred fifteen HL and DLBCL survivors (mean age = 40.3 years, mean months since completed treatment = 29.6) completed questionnaires on executive function and mental health. We examined the prevalence of executive impairment and compared illness and treatment characteristics and mental health across survivors reporting impaired and non-impaired executive functioning using chi-square, Cochran-Armitage, and Mann-Whitney U tests.RESULTS: We found that 39% reported executive impairment. Survivors reporting impaired executive functioning reported worse mental health (ps < .001) than survivors reporting non-impaired executive functioning. A larger proportion of the impaired group had received a high chemo dose compared to the non-impaired group although this result fell short of significance after adjustment for multiple comparisons (p = .017).CONCLUSIONS: Self-reported cognitive impairment is prevalent in HL and DLBCL survivors and is associated with worse mental health and possibly high chemo dose. Future studies should investigate objective impairment and the possible dose-response relationship between chemo dose and cognitive impairment in lymphoma survivors.

KW - Cancer-related cognitive impairment

KW - Hodgkin lymphoma

KW - Diffuse large B cell lymphoma

KW - Self-reported cognitive function

KW - Mental health

KW - Hodgkin Disease/complications

KW - Cognitive Dysfunction/etiology

KW - Cancer Survivors

KW - Prevalence

KW - Humans

KW - Middle Aged

KW - Male

KW - Young Adult

KW - Denmark

KW - Adult

KW - Female

KW - Executive Function/physiology

KW - Mental Health/standards

U2 - 10.1007/s00520-020-05857-4

DO - 10.1007/s00520-020-05857-4

M3 - Journal article

C2 - 33118105

VL - 29

SP - 3319

EP - 3328

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 6

ER -

ID: 61822545