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Prevalence and outcomes of pregnancies in women with HIV over a 20-year period: The EuroSIDA study, 1996 to 2015

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@article{039a6b1a804940d6a4c93cf6596688e7,
title = "Prevalence and outcomes of pregnancies in women with HIV over a 20-year period: The EuroSIDA study, 1996 to 2015",
abstract = "OBJECTIVE: To evaluate time trends in pregnancies and pregnancy outcomes among women with HIV in Europe.DESIGN: European multicentre prospective cohort study.METHODS: EuroSIDA has collected annual cross-sectional audits of pregnancies between 1996 and 2015. Pregnancy data were extracted and described. Odds of pregnancy were modelled, adjusting for potential confounders using logistic regression with generalized estimating equations.RESULTS: Of 5535 women aged 16 to <50 years, 4217 (76.2%) had pregnancy information available, and 912 (21.6%) reported 1315 pregnancies. The proportions with at least one pregnancy were 28.1% (321/1143) in East, 24.5% (146/596) in North, 19.8% (140/706) in West/Central, 19.3% (110/569) in Central East and 16.2% (195/1203) in South Europe. Overall 319 pregnancies (24.3%) occurred in 1996-2002, 576 (43.8%) in 2003-2009 and 420 (31.9%) in 2010-2015. After adjustment, the odds of pregnancy were lower in 1996-2002, in South, Central East and East compared to West/Central Europe, in older women, those with low CD4+ cell count or with prior AIDS, and higher in those with a previous pregnancy or who were hepatitis C virus positive.Outcomes were reported for 999 pregnancies in 1996-2014, with 690 live births (69.1%), seven stillbirths (0.7%), 103 spontaneous (10.3%) and 199 medical abortions (19.9%).CONCLUSIONS: Around 20% of women in EuroSIDA reported a pregnancy, with most pregnancies after 2002, when more effective antiretroviral therapy became available. Substantial differences were seen between European regions. Further surveillance of pregnancies and outcomes among women living with HIV is warranted to ensure equal access to care.",
keywords = "Abortion, Induced, Aged, Cross-Sectional Studies, Female, HIV Infections/epidemiology, Humans, Pregnancy, Prevalence, Prospective Studies",
author = "Kowalska, {Justyna D} and Annegret Pelchen-Matthews and Lene Ryom and Losso, {Marcelo H} and Tatiana Trofimova and Mitsura, {Viktar M} and Irina Khromova and Dzmitry Paduta and Christoph Stephan and Pere Domingo and Elzbieta Bakowska and Monforte, {Antonella d'Arminio} and Lars Oestergaard and Elzbieta Jablonowska and Anastasiia Kuznetsova and Santiago Moreno and Marta Vasylyev and Christian Pradier and Manuel Battegay and Linos Vandekerckhove and Antonella Castagna and Dorthe Raben and Amanda Mocroft and {EuroSIDA study group}",
note = "Copyright {\textcopyright} 2021 Wolters Kluwer Health, Inc.",
year = "2021",
month = oct,
day = "1",
doi = "10.1097/QAD.0000000000002954",
language = "English",
volume = "35",
pages = "2025--2033",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams & Wilkins",
number = "12",

}

RIS

TY - JOUR

T1 - Prevalence and outcomes of pregnancies in women with HIV over a 20-year period

T2 - The EuroSIDA study, 1996 to 2015

AU - Kowalska, Justyna D

AU - Pelchen-Matthews, Annegret

AU - Ryom, Lene

AU - Losso, Marcelo H

AU - Trofimova, Tatiana

AU - Mitsura, Viktar M

AU - Khromova, Irina

AU - Paduta, Dzmitry

AU - Stephan, Christoph

AU - Domingo, Pere

AU - Bakowska, Elzbieta

AU - Monforte, Antonella d'Arminio

AU - Oestergaard, Lars

AU - Jablonowska, Elzbieta

AU - Kuznetsova, Anastasiia

AU - Moreno, Santiago

AU - Vasylyev, Marta

AU - Pradier, Christian

AU - Battegay, Manuel

AU - Vandekerckhove, Linos

AU - Castagna, Antonella

AU - Raben, Dorthe

AU - Mocroft, Amanda

AU - EuroSIDA study group

N1 - Copyright © 2021 Wolters Kluwer Health, Inc.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - OBJECTIVE: To evaluate time trends in pregnancies and pregnancy outcomes among women with HIV in Europe.DESIGN: European multicentre prospective cohort study.METHODS: EuroSIDA has collected annual cross-sectional audits of pregnancies between 1996 and 2015. Pregnancy data were extracted and described. Odds of pregnancy were modelled, adjusting for potential confounders using logistic regression with generalized estimating equations.RESULTS: Of 5535 women aged 16 to <50 years, 4217 (76.2%) had pregnancy information available, and 912 (21.6%) reported 1315 pregnancies. The proportions with at least one pregnancy were 28.1% (321/1143) in East, 24.5% (146/596) in North, 19.8% (140/706) in West/Central, 19.3% (110/569) in Central East and 16.2% (195/1203) in South Europe. Overall 319 pregnancies (24.3%) occurred in 1996-2002, 576 (43.8%) in 2003-2009 and 420 (31.9%) in 2010-2015. After adjustment, the odds of pregnancy were lower in 1996-2002, in South, Central East and East compared to West/Central Europe, in older women, those with low CD4+ cell count or with prior AIDS, and higher in those with a previous pregnancy or who were hepatitis C virus positive.Outcomes were reported for 999 pregnancies in 1996-2014, with 690 live births (69.1%), seven stillbirths (0.7%), 103 spontaneous (10.3%) and 199 medical abortions (19.9%).CONCLUSIONS: Around 20% of women in EuroSIDA reported a pregnancy, with most pregnancies after 2002, when more effective antiretroviral therapy became available. Substantial differences were seen between European regions. Further surveillance of pregnancies and outcomes among women living with HIV is warranted to ensure equal access to care.

AB - OBJECTIVE: To evaluate time trends in pregnancies and pregnancy outcomes among women with HIV in Europe.DESIGN: European multicentre prospective cohort study.METHODS: EuroSIDA has collected annual cross-sectional audits of pregnancies between 1996 and 2015. Pregnancy data were extracted and described. Odds of pregnancy were modelled, adjusting for potential confounders using logistic regression with generalized estimating equations.RESULTS: Of 5535 women aged 16 to <50 years, 4217 (76.2%) had pregnancy information available, and 912 (21.6%) reported 1315 pregnancies. The proportions with at least one pregnancy were 28.1% (321/1143) in East, 24.5% (146/596) in North, 19.8% (140/706) in West/Central, 19.3% (110/569) in Central East and 16.2% (195/1203) in South Europe. Overall 319 pregnancies (24.3%) occurred in 1996-2002, 576 (43.8%) in 2003-2009 and 420 (31.9%) in 2010-2015. After adjustment, the odds of pregnancy were lower in 1996-2002, in South, Central East and East compared to West/Central Europe, in older women, those with low CD4+ cell count or with prior AIDS, and higher in those with a previous pregnancy or who were hepatitis C virus positive.Outcomes were reported for 999 pregnancies in 1996-2014, with 690 live births (69.1%), seven stillbirths (0.7%), 103 spontaneous (10.3%) and 199 medical abortions (19.9%).CONCLUSIONS: Around 20% of women in EuroSIDA reported a pregnancy, with most pregnancies after 2002, when more effective antiretroviral therapy became available. Substantial differences were seen between European regions. Further surveillance of pregnancies and outcomes among women living with HIV is warranted to ensure equal access to care.

KW - Abortion, Induced

KW - Aged

KW - Cross-Sectional Studies

KW - Female

KW - HIV Infections/epidemiology

KW - Humans

KW - Pregnancy

KW - Prevalence

KW - Prospective Studies

UR - http://www.scopus.com/inward/record.url?scp=85115443848&partnerID=8YFLogxK

U2 - 10.1097/QAD.0000000000002954

DO - 10.1097/QAD.0000000000002954

M3 - Journal article

C2 - 34033590

VL - 35

SP - 2025

EP - 2033

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 12

ER -

ID: 65837698