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Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs

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Author

Sangild, Per T ; Petersen, Yvette M ; Schmidt, Mette ; Elnif, Jan ; Petersen, Thomas K ; Buddington, Randal K ; Greisen, Gorm ; Michaelsen, Kim F ; Burrin, Douglas G. / Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs. I: Journal of Nutrition. 2003 ; Bind 132, Nr. 12. s. 3786-94.

Bibtex

@article{a5723bac71fe486b91dca2577c88f4a5,
title = "Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs",
abstract = "Maturation of gastrointestinal (GI) function in neonates is stimulated by enteral nutrition, whereas parenteral nutrition induces GI atrophy and malfunction. We investigated whether preterm birth alters the GI responses to parenteral and enteral nutrition. Pigs were delivered either preterm (107 d gestation) or at term (115 d gestation) and fed total parenteral nutrition (TPN) or enteral sow's milk (ENT) for 6 d after birth. Immaturity of the preterm pigs was documented by reduced blood pH, oxygen saturation and neutrophil granulocyte function, impaired intestinal immunoglobulin G uptake from colostrum, and altered relative weights of visceral organs (small intestine, liver, spleen, pancreas, and adrenals). For both ages at delivery, increases occurred in pancreatic weight (30-75{\%}) and amylase activity (0.5- to 13-fold) after birth, but much more in ENT than in TPN pigs (P < 0.05). Six days of TPN feeding was associated with reduced intestinal weight for both delivery groups (60{\%} of values in ENT, P < 0.001), but only in term TPN pigs was the weight lower than at birth (-20{\%}, P < 0.05). Likewise, it was only in term TPN pigs that intestinal maltase activity increased, compared with ENT, and the absorption of glucose and proline decreased. Only in preterm pigs did TPN feeding increase lactase activity (+50{\%} compared with ENT, P < 0.05). For both delivery ages, the mRNA of lactase-phloridzin hydrolase and sodium-coupled glucose transporter 1 (SGLT-1) were increased in TPN, compared with ENT. In conclusion, the trophic effect of enteral vs. parenteral nutrition on the GI tract is also present after preterm birth, but the postnatal maturation of many GI functions is modified, compared with term birth. The effects of nutritional regimen on the maturation of the gut epithelium in neonates depend on gestational age at birth.",
keywords = "Animals, Animals, Newborn, Base Sequence, DNA Primers, Enteral Nutrition, Intestinal Absorption, Intestines/enzymology, Organ Size, Pancreas/enzymology, Parenteral Nutrition, Swine",
author = "Sangild, {Per T} and Petersen, {Yvette M} and Mette Schmidt and Jan Elnif and Petersen, {Thomas K} and Buddington, {Randal K} and Gorm Greisen and Michaelsen, {Kim F} and Burrin, {Douglas G}",
year = "2003",
month = "12",
doi = "10.1093/jn/132.9.2673",
language = "English",
volume = "132",
pages = "3786--94",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "12",

}

RIS

TY - JOUR

T1 - Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs

AU - Sangild, Per T

AU - Petersen, Yvette M

AU - Schmidt, Mette

AU - Elnif, Jan

AU - Petersen, Thomas K

AU - Buddington, Randal K

AU - Greisen, Gorm

AU - Michaelsen, Kim F

AU - Burrin, Douglas G

PY - 2003/12

Y1 - 2003/12

N2 - Maturation of gastrointestinal (GI) function in neonates is stimulated by enteral nutrition, whereas parenteral nutrition induces GI atrophy and malfunction. We investigated whether preterm birth alters the GI responses to parenteral and enteral nutrition. Pigs were delivered either preterm (107 d gestation) or at term (115 d gestation) and fed total parenteral nutrition (TPN) or enteral sow's milk (ENT) for 6 d after birth. Immaturity of the preterm pigs was documented by reduced blood pH, oxygen saturation and neutrophil granulocyte function, impaired intestinal immunoglobulin G uptake from colostrum, and altered relative weights of visceral organs (small intestine, liver, spleen, pancreas, and adrenals). For both ages at delivery, increases occurred in pancreatic weight (30-75%) and amylase activity (0.5- to 13-fold) after birth, but much more in ENT than in TPN pigs (P < 0.05). Six days of TPN feeding was associated with reduced intestinal weight for both delivery groups (60% of values in ENT, P < 0.001), but only in term TPN pigs was the weight lower than at birth (-20%, P < 0.05). Likewise, it was only in term TPN pigs that intestinal maltase activity increased, compared with ENT, and the absorption of glucose and proline decreased. Only in preterm pigs did TPN feeding increase lactase activity (+50% compared with ENT, P < 0.05). For both delivery ages, the mRNA of lactase-phloridzin hydrolase and sodium-coupled glucose transporter 1 (SGLT-1) were increased in TPN, compared with ENT. In conclusion, the trophic effect of enteral vs. parenteral nutrition on the GI tract is also present after preterm birth, but the postnatal maturation of many GI functions is modified, compared with term birth. The effects of nutritional regimen on the maturation of the gut epithelium in neonates depend on gestational age at birth.

AB - Maturation of gastrointestinal (GI) function in neonates is stimulated by enteral nutrition, whereas parenteral nutrition induces GI atrophy and malfunction. We investigated whether preterm birth alters the GI responses to parenteral and enteral nutrition. Pigs were delivered either preterm (107 d gestation) or at term (115 d gestation) and fed total parenteral nutrition (TPN) or enteral sow's milk (ENT) for 6 d after birth. Immaturity of the preterm pigs was documented by reduced blood pH, oxygen saturation and neutrophil granulocyte function, impaired intestinal immunoglobulin G uptake from colostrum, and altered relative weights of visceral organs (small intestine, liver, spleen, pancreas, and adrenals). For both ages at delivery, increases occurred in pancreatic weight (30-75%) and amylase activity (0.5- to 13-fold) after birth, but much more in ENT than in TPN pigs (P < 0.05). Six days of TPN feeding was associated with reduced intestinal weight for both delivery groups (60% of values in ENT, P < 0.001), but only in term TPN pigs was the weight lower than at birth (-20%, P < 0.05). Likewise, it was only in term TPN pigs that intestinal maltase activity increased, compared with ENT, and the absorption of glucose and proline decreased. Only in preterm pigs did TPN feeding increase lactase activity (+50% compared with ENT, P < 0.05). For both delivery ages, the mRNA of lactase-phloridzin hydrolase and sodium-coupled glucose transporter 1 (SGLT-1) were increased in TPN, compared with ENT. In conclusion, the trophic effect of enteral vs. parenteral nutrition on the GI tract is also present after preterm birth, but the postnatal maturation of many GI functions is modified, compared with term birth. The effects of nutritional regimen on the maturation of the gut epithelium in neonates depend on gestational age at birth.

KW - Animals

KW - Animals, Newborn

KW - Base Sequence

KW - DNA Primers

KW - Enteral Nutrition

KW - Intestinal Absorption

KW - Intestines/enzymology

KW - Organ Size

KW - Pancreas/enzymology

KW - Parenteral Nutrition

KW - Swine

U2 - 10.1093/jn/132.9.2673

DO - 10.1093/jn/132.9.2673

M3 - Journal article

VL - 132

SP - 3786

EP - 3794

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 12

ER -

ID: 58216648