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Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort

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Harvard

Olesen, TS, Bleses, D, Andersen, HR, Grandjean, P, Frederiksen, H, Trecca, F, Bilenberg, N, Kyhl, HB, Dalsager, L, Jensen, IK, Andersson, A-M & Jensen, TK 2018, 'Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort', Neurotoxicology and Teratology, bind 65, s. 34-41. https://doi.org/10.1016/j.ntt.2017.11.004

APA

Olesen, T. S., Bleses, D., Andersen, H. R., Grandjean, P., Frederiksen, H., Trecca, F., Bilenberg, N., Kyhl, H. B., Dalsager, L., Jensen, I. K., Andersson, A-M., & Jensen, T. K. (2018). Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort. Neurotoxicology and Teratology, 65, 34-41. https://doi.org/10.1016/j.ntt.2017.11.004

CBE

Olesen TS, Bleses D, Andersen HR, Grandjean P, Frederiksen H, Trecca F, Bilenberg N, Kyhl HB, Dalsager L, Jensen IK, Andersson A-M, Jensen TK. 2018. Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort. Neurotoxicology and Teratology. 65:34-41. https://doi.org/10.1016/j.ntt.2017.11.004

MLA

Vancouver

Author

Olesen, Trine Staak ; Bleses, Dorthe ; Andersen, Helle Raun ; Grandjean, Philippe ; Frederiksen, Hanne ; Trecca, Fabio ; Bilenberg, Niels ; Kyhl, Henriette Boye ; Dalsager, Louise ; Jensen, Inge Kjær ; Andersson, Anna-Maria ; Jensen, Tina Kold. / Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort. I: Neurotoxicology and Teratology. 2018 ; Bind 65. s. 34-41.

Bibtex

@article{f86cfb4de1ef4ea98b4af0f58183043a,
title = "Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort",
abstract = "BACKGROUND: Phthalates are a group of chemicals found in a variety of consumer products. They have anti-androgenic properties and human studies have reported associations between prenatal phthalate exposure and neuropsychological development in the offspring despite different cognitive tests, different ages and varying timing of exposure.OBJECTIVES: To investigate the association between prenatal phthalate exposure and language development in children aged 20-36months.METHODS: In the Odense Child Cohort, we analyzed 3rd trimester urine samples of 518 pregnant women for content of metabolites of diethyl, di-n-butyl, diisobutyl, butylbenzyl, di(2-ethylhexyl), and diisononyl phthalate, adjusted for osmolality. Language development was addressed using the Danish version of the MacArthur-Bates Communicative Development Inventories {"}Words and Sentences{"}. Associations were assessed using logistic regression models comparing children below and above the 15th percentile while stratifying by sex and adjusting for maternal age and educational level.RESULTS: Phthalate metabolites were detectable in all samples although in lower levels than previous studies. Among boys, increased prenatal phthalate exposure was associated with lower scores in language development; odds ratios for vocabulary score below the 15th percentile with doubling in monoethyl phthalate, and summed di-(2-ethylhexyl) phthalate metabolites were respectively 1.24 (95% confidence interval: 1.05,1.46), and 1.33 (1.01,1.75). Similar associations were found for language complexity. No associations were found for girls.CONCLUSIONS: Our findings are notable, as adverse associations were suggested even in this low-level exposed population, with only one spot urine sample for exposure assessment and control for confounders. Lower scores in early language development are of relevance to health as this test predicts later educational success.",
keywords = "Journal Article",
author = "Olesen, {Trine Staak} and Dorthe Bleses and Andersen, {Helle Raun} and Philippe Grandjean and Hanne Frederiksen and Fabio Trecca and Niels Bilenberg and Kyhl, {Henriette Boye} and Louise Dalsager and Jensen, {Inge Kj{\ae}r} and Anna-Maria Andersson and Jensen, {Tina Kold}",
note = "Copyright {\textcopyright} 2017. Published by Elsevier Inc.",
year = "2018",
doi = "10.1016/j.ntt.2017.11.004",
language = "English",
volume = "65",
pages = "34--41",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc",

}

RIS

TY - JOUR

T1 - Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort

AU - Olesen, Trine Staak

AU - Bleses, Dorthe

AU - Andersen, Helle Raun

AU - Grandjean, Philippe

AU - Frederiksen, Hanne

AU - Trecca, Fabio

AU - Bilenberg, Niels

AU - Kyhl, Henriette Boye

AU - Dalsager, Louise

AU - Jensen, Inge Kjær

AU - Andersson, Anna-Maria

AU - Jensen, Tina Kold

N1 - Copyright © 2017. Published by Elsevier Inc.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Phthalates are a group of chemicals found in a variety of consumer products. They have anti-androgenic properties and human studies have reported associations between prenatal phthalate exposure and neuropsychological development in the offspring despite different cognitive tests, different ages and varying timing of exposure.OBJECTIVES: To investigate the association between prenatal phthalate exposure and language development in children aged 20-36months.METHODS: In the Odense Child Cohort, we analyzed 3rd trimester urine samples of 518 pregnant women for content of metabolites of diethyl, di-n-butyl, diisobutyl, butylbenzyl, di(2-ethylhexyl), and diisononyl phthalate, adjusted for osmolality. Language development was addressed using the Danish version of the MacArthur-Bates Communicative Development Inventories "Words and Sentences". Associations were assessed using logistic regression models comparing children below and above the 15th percentile while stratifying by sex and adjusting for maternal age and educational level.RESULTS: Phthalate metabolites were detectable in all samples although in lower levels than previous studies. Among boys, increased prenatal phthalate exposure was associated with lower scores in language development; odds ratios for vocabulary score below the 15th percentile with doubling in monoethyl phthalate, and summed di-(2-ethylhexyl) phthalate metabolites were respectively 1.24 (95% confidence interval: 1.05,1.46), and 1.33 (1.01,1.75). Similar associations were found for language complexity. No associations were found for girls.CONCLUSIONS: Our findings are notable, as adverse associations were suggested even in this low-level exposed population, with only one spot urine sample for exposure assessment and control for confounders. Lower scores in early language development are of relevance to health as this test predicts later educational success.

AB - BACKGROUND: Phthalates are a group of chemicals found in a variety of consumer products. They have anti-androgenic properties and human studies have reported associations between prenatal phthalate exposure and neuropsychological development in the offspring despite different cognitive tests, different ages and varying timing of exposure.OBJECTIVES: To investigate the association between prenatal phthalate exposure and language development in children aged 20-36months.METHODS: In the Odense Child Cohort, we analyzed 3rd trimester urine samples of 518 pregnant women for content of metabolites of diethyl, di-n-butyl, diisobutyl, butylbenzyl, di(2-ethylhexyl), and diisononyl phthalate, adjusted for osmolality. Language development was addressed using the Danish version of the MacArthur-Bates Communicative Development Inventories "Words and Sentences". Associations were assessed using logistic regression models comparing children below and above the 15th percentile while stratifying by sex and adjusting for maternal age and educational level.RESULTS: Phthalate metabolites were detectable in all samples although in lower levels than previous studies. Among boys, increased prenatal phthalate exposure was associated with lower scores in language development; odds ratios for vocabulary score below the 15th percentile with doubling in monoethyl phthalate, and summed di-(2-ethylhexyl) phthalate metabolites were respectively 1.24 (95% confidence interval: 1.05,1.46), and 1.33 (1.01,1.75). Similar associations were found for language complexity. No associations were found for girls.CONCLUSIONS: Our findings are notable, as adverse associations were suggested even in this low-level exposed population, with only one spot urine sample for exposure assessment and control for confounders. Lower scores in early language development are of relevance to health as this test predicts later educational success.

KW - Journal Article

U2 - 10.1016/j.ntt.2017.11.004

DO - 10.1016/j.ntt.2017.11.004

M3 - Journal article

C2 - 29198963

VL - 65

SP - 34

EP - 41

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

ER -

ID: 52794167