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Prematurity Reduces Functional Adaptation to Intestinal Resection in Piglets

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Gut and immune effects of bioactive milk factors in preterm pigs exposed to prenatal inflammation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pathogenesis and biomarkers for necrotizing enterocolitis: Getting any closer?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Lise Aunsholt
  • Thomas Thymann
  • Niels Qvist
  • David Sigalet
  • Steffen Husby
  • Per Torp Sangild
Vis graf over relationer

BACKGROUND: Necrotizing enterocolitis and congenital gastrointestinal malformations in infants often require intestinal resection, with a subsequent risk of short bowel syndrome (SBS). We hypothesized that immediate intestinal adaptation following resection of the distal intestine with placement of a jejunostomy differs between preterm and term neonates.

METHODS: Preterm or term piglets were born by cesarean section and fed enterally for 2 days. On day 2, piglets were subjected to 50% distal intestinal resection with placement of a jejunostomy. On the following 4-5 days, piglets received parenteral nutrition with gradually increasing doses of enteral nutrition (bovine colostrum). Intestinal tissue samples were collected at delivery and 2 and 6-7 days after birth for histological examination and assessment of digestive enzyme activities.

RESULTS: Preterm and term piglets showed similar increases in intestinal weight and digestive enzyme activities from birth to 2 days. On days 6-7 after birth, the remnant intestine showed a similar density (g/cm) and mucosal mass in term and preterm piglets, but villus height, crypt depth, enzyme activities (sucrase, maltase, dipeptidyl peptidase IV [DPPIV]), and hexose uptake capacity were significantly higher in term piglets (P < .05). Preterm piglets were more prone to develop hypoglycemia, respiratory distress syndrome, dehydration, and circulatory instability after surgery compared with term piglets.

CONCLUSION: Studies on intestinal adaptation after resection are feasible in both preterm and term piglets, but intensive clinical support is required when rearing preterm piglets with SBS. Physiological instability and immaturity of the intestine may explain the fact that immediate adaptation after resection is reduced in preterm vs term neonates.

OriginalsprogEngelsk
TidsskriftJournal of Parenteral and Enteral Nutrition
Vol/bind39
Udgave nummer6
Sider (fra-til)668-76
Antal sider9
ISSN0148-6071
DOI
StatusUdgivet - aug. 2015

ID: 46276950