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Pregnancy outcomes after recurrent pregnancy loss: a longitudinal cohort study on stress and depression

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@article{c5735579821545a3bcc3a8beb757f362,
title = "Pregnancy outcomes after recurrent pregnancy loss: a longitudinal cohort study on stress and depression",
abstract = "Research QuestionAre self-reported symptoms of stress and depression associated with pregnancy outcomes within the first year after referral to a tertiary recurrent pregnancy loss unit?DesignProspective cohort study with online questionnaires using the Major Depression Inventory (MDI) and Cohen's Stress Scale (PSS) at referral and after one year. The study was conducted between 2010 and 2014. A total of 301 women with recurrent pregnancy loss completed the first questionnaire. One year after referral, 185 women (61{\%}) completed a follow-up questionnaire.ResultsA score above the threshold for major depression on the MDI at referral was not a predictor for outcome in the first pregnancy after referral; OR (95{\%} CI) for live birth 1.71 (0.66; 4.44), nor was increasing scores on the PSS: OR 0.98 (95{\%} CI 0.94; 1.02). At follow-up, women who had achieved a pregnancy which ended with the birth of a live born child had significantly lower scores on both the MDI: 13.45 (11.05) versus 11.04 (11.07), difference -2.41 (95{\%} CI -4.60; -0.23) and the PSS: mean 17.69 (7.59) versus 13.03 (6.83), difference -4.66 (95{\%} CI -6.04; -3.28), respectively. This was not the case for women who did not have a successful pregnancy. Women with recurrent pregnancy loss after a child were less likely to report symptoms corresponding to major depression than women with only losses (n=7 (5{\%}) vs. 19 (12{\%}), p=0.04).ConclusionsSelf-reported emotional distress did not impact future chance of live birth in this cohort. A live born child decreased emotional distress.",
author = "Kolte, {Astrid Marie} and {Raab{\ae}k Olsen}, Lis and OB Christiansen and L Schmidt and Nielsen, {Henriette Svarre}",
year = "2019",
month = "4",
day = "1",
doi = "https://doi.org/10.1016/j.rbmo.2018.12.006",
language = "Dansk",
volume = "38",
pages = "599--605",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Reproductive Healthcare Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Pregnancy outcomes after recurrent pregnancy loss

T2 - a longitudinal cohort study on stress and depression

AU - Kolte, Astrid Marie

AU - Raabæk Olsen, Lis

AU - Christiansen, OB

AU - Schmidt, L

AU - Nielsen, Henriette Svarre

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Research QuestionAre self-reported symptoms of stress and depression associated with pregnancy outcomes within the first year after referral to a tertiary recurrent pregnancy loss unit?DesignProspective cohort study with online questionnaires using the Major Depression Inventory (MDI) and Cohen's Stress Scale (PSS) at referral and after one year. The study was conducted between 2010 and 2014. A total of 301 women with recurrent pregnancy loss completed the first questionnaire. One year after referral, 185 women (61%) completed a follow-up questionnaire.ResultsA score above the threshold for major depression on the MDI at referral was not a predictor for outcome in the first pregnancy after referral; OR (95% CI) for live birth 1.71 (0.66; 4.44), nor was increasing scores on the PSS: OR 0.98 (95% CI 0.94; 1.02). At follow-up, women who had achieved a pregnancy which ended with the birth of a live born child had significantly lower scores on both the MDI: 13.45 (11.05) versus 11.04 (11.07), difference -2.41 (95% CI -4.60; -0.23) and the PSS: mean 17.69 (7.59) versus 13.03 (6.83), difference -4.66 (95% CI -6.04; -3.28), respectively. This was not the case for women who did not have a successful pregnancy. Women with recurrent pregnancy loss after a child were less likely to report symptoms corresponding to major depression than women with only losses (n=7 (5%) vs. 19 (12%), p=0.04).ConclusionsSelf-reported emotional distress did not impact future chance of live birth in this cohort. A live born child decreased emotional distress.

AB - Research QuestionAre self-reported symptoms of stress and depression associated with pregnancy outcomes within the first year after referral to a tertiary recurrent pregnancy loss unit?DesignProspective cohort study with online questionnaires using the Major Depression Inventory (MDI) and Cohen's Stress Scale (PSS) at referral and after one year. The study was conducted between 2010 and 2014. A total of 301 women with recurrent pregnancy loss completed the first questionnaire. One year after referral, 185 women (61%) completed a follow-up questionnaire.ResultsA score above the threshold for major depression on the MDI at referral was not a predictor for outcome in the first pregnancy after referral; OR (95% CI) for live birth 1.71 (0.66; 4.44), nor was increasing scores on the PSS: OR 0.98 (95% CI 0.94; 1.02). At follow-up, women who had achieved a pregnancy which ended with the birth of a live born child had significantly lower scores on both the MDI: 13.45 (11.05) versus 11.04 (11.07), difference -2.41 (95% CI -4.60; -0.23) and the PSS: mean 17.69 (7.59) versus 13.03 (6.83), difference -4.66 (95% CI -6.04; -3.28), respectively. This was not the case for women who did not have a successful pregnancy. Women with recurrent pregnancy loss after a child were less likely to report symptoms corresponding to major depression than women with only losses (n=7 (5%) vs. 19 (12%), p=0.04).ConclusionsSelf-reported emotional distress did not impact future chance of live birth in this cohort. A live born child decreased emotional distress.

U2 - https://doi.org/10.1016/j.rbmo.2018.12.006

DO - https://doi.org/10.1016/j.rbmo.2018.12.006

M3 - Tidsskriftartikel

VL - 38

SP - 599

EP - 605

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 4

ER -

ID: 56241316