Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Predictive value of combined analysis of pro-NPY and ERG in localized prostate cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Bacteremia and urogenital infection with Actinomyces urogenitalis following prolonged urinary retention

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Analysis of proximal bone margins in diabetic foot osteomyelitis by conventional culture, DNA sequencing and microscopy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. L-serine: a neglected amino acid with a potential therapeutic role in diabetes

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Erythrocytes restrict microvesicle-induced production of reactive oxygen species by polymorphonuclear leukocytes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Palliative Prostate Artery Embolization for Prostate Cancer: A Case Series

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Predictive value of AZGP1 following radical prostatectomy for prostate cancer: a cohort study and meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Prognostic factors for relapse in patients with clinical stage I testicular cancer: Protocol for a Danish nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Community-based football in men with prostate cancer: 1-year follow-up on a pragmatic, multicentre randomised controlled trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

This study aimed to investigate if combined analysis of pro-Neuropeptide Y (NPY) and ERG expression in tumor tissue are associated with biochemical failure (BF), castration-based treatment, castration-resistant prostate cancer (CRPC), and prostate cancer (PCa)-specific death for men undergoing radical prostatectomy (RP) for PCa. This study included 315 patients, who underwent RP from 2002 to 2005. Both pro-NPY and ERG expression were analyzed using immunohistochemistry and were scored as low or high and negative or positive, respectively. Risk of BF, castration-based treatment, CRPC, and PCa-specific death were analyzed with multiple cause-specific Cox regression analyses and stratified cumulative incidences using competing risk assessment. Median follow-up was 13.0 years (95% CI: 12.7-13.2). In total, 85.7% were pro-NPY high and 14.3% were pro-NPY low. The combined analyses of pro-NPY and ERG expression was not associated with risk of BF (p = 0.7), castration-based treatment (p = 0.8), CRPC (p = 0.4) or PCa-specific death (p = 0.5). In the multiple cause-specific Cox regression analysis, pro-NPY high and ERG positivity was not associated with BF (HR: 1.02; 95% CI 0.6-1.7; p = 0.94). In conclusion the combination of pro-NPY and ERG expression did not show association with risk of BF, castration-based treatment, CRPC, and PCa-specific death following RP.

OriginalsprogEngelsk
TidsskriftAPMIS - Journal of Pathology, Microbiology and Immunology
Vol/bind126
Udgave nummer10
Sider (fra-til)804-813
Antal sider10
ISSN0903-4641
DOI
StatusUdgivet - okt. 2018

ID: 55350213