Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Predictive Importance of Blood Pressure Characteristics With Increasing Age in Healthy Men and Women: The MORGAM Project

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Does Estimated Pulse Wave Velocity Add Prognostic Information? MORGAM Prospective Cohort Project

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Level of Physical Activity, Left Ventricular Mass, Hypertension, and Prognosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Abdominal Adiposity Distribution Quantified by Ultrasound Imaging and Incident Hypertension in a General Population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Prognosis in relation to blood pressure variability: con side of the argument

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Symptoms and biomarkers associated with undiagnosed celiac seropositivity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

It remains unclear which blood pressure (BP) characteristics best predict cardiovascular risk in different age groups and between sexes. We leveraged data from the MORGAM (MONICA [Monitoring of Trends and Determinants in Cardiovascular Disease], Risk, Genetics, Archiving and Monograph) Project to investigate determinants of BP characteristics and their prognostic importance, in younger and older (</≥50 years) men and women. The study population comprised 107 599 individuals (53% men) aged 19 to 97 years without established cardiovascular disease, not on antihypertensive treatment, recruited between 1982 and 2008 in 38 cohorts. Covariates of BP characteristics were explored using multivariable linear regression. Prognostic importance was examined using multivariable Cox proportional-hazards regression, area under the receiver operating characteristic curve, and net reclassification improvement. The primary end point was a composite cardiovascular end point (CEP), defined as fatal or nonfatal stroke, death from coronary heart disease or nonfatal myocardial infarction. The positive association between age and systolic BP was more pronounced among individuals ≥50 years while the same was true for diastolic BP in those <50 years (P interaction <0.001). Higher systolic BP and mean BP were significantly associated with cardiovascular end point, irrespective of age group (P<0.001), but diastolic BP only demonstrated an independent relationship in the younger group (P<0.001). Brachial pulse pressure was associated with cardiovascular end point in the older age group (P<0.001). In subjects <50 years, diastolic BP significantly improved area under the receiver operating characteristic curve compared with Systematic Coronary Risk Evaluation variables (including systolic BP) alone (0.842 versus 0.840, P=0.03), enhanced continuous net reclassification improvement (0.150 [95% CI, 0.087-0.215]) and improved the prognostic value of the European Society of Cardiology/European Society of Hypertension hypertension definition (categorical net reclassification improvement=0.0255, P=0.005). In conclusion, diastolic BP may provide additional prognostic utility beyond systolic BP, in predicting composite cardiovascular events among younger individuals.

OriginalsprogEngelsk
TidsskriftHypertension
Vol/bind77
Udgave nummer4
Sider (fra-til)1076-1085
Antal sider10
ISSN0194-911X
DOI
StatusUdgivet - apr. 2021

ID: 63844902