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Rigshospitalet - en del af Københavns Universitetshospital
Accepteret/In press

Prediction of Pathologic Complete Response in Breast Cancer Patients Comparing Magnetic Resonance Imaging with Ultrasound in Neoadjuvant Setting

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. A Standard Set of Value-Based Patient-Centered Outcomes for Pancreatic Carcinoma: An International Delphi Survey

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A Nomogram for Predicting Cancer-Specific Survival of TNM 8th Edition Stage I Non-small-cell Lung Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Variations in surgical cancer treatment in Denmark- regional variations in pancreatic, kidney, and bladder cancer

    Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  3. Breast cancer mortality and overdiagnosis after implementation of population-based screening in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background: Some subgroups of breast cancer patients receiving neoadjuvant chemotherapy (NACT) show high rates of pathologic complete response (pCR) in the breast, proposing the possibility of omitting surgery. Prediction of pCR is dependent on accurate imaging methods. This study investigated whether magnetic resonance imaging (MRI) is better than ultrasound (US) in predicting pCR in breast cancer patients receiving NACT. Methods: This institutional, retrospective study enrolled breast cancer patients receiving NACT who were examined by either MRI or combined US and mammography before surgery from 2016 to 2019. Imaging findings were compared with pathologic response evaluation of the tumor. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for prediction of pCR were calculated and compared between MRI and US. Results: Among 307 patients, 151 were examined by MRI and 156 by US. In the MRI group, 37 patients (24.5 %) had a pCR compared with 51 patients (32.7 %) in the US group. Radiologic complete response (rCR) was found in 35 patients (23.2 %) in the MRI group and 26 patients (16.7 %) in the US group. In the MRI and US groups, estimates were calculated respectively for sensitivity (87.7 % vs 91.4 %), specificity (56.8 % vs 33.3 %), PPV (86.2 % vs 73.8 %), NPV (60.0 % vs 65.4 %), and accuracy (80.1 % vs 72.4 %). Conclusions: In predicting pCR, MRI was more specific than US, but not sufficiently specific enough to be a valid predictor of pCR for omission of surgery. As an imaging method, MRI should be preferred when future studies investigating prediction of pCR in NACT patients are planned.

TidsskriftAnnals of Surgical Oncology
StatusAccepteret/In press - 2021

Bibliografisk note

Publisher Copyright:
© 2021, Society of Surgical Oncology.

Copyright 2021 Elsevier B.V., All rights reserved.

ID: 66208768