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Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

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@article{322d5e961ede4e93add89a37b70b8a9d,
title = "Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes",
abstract = "AIMS: To investigate measures of carotid intima-media thickness (IMT) and conventional cardiovascular (CV) risk factors as predictors of future carotid IMT, and the prediction of CV events during follow-up based on measures of carotid IMT.METHODS: Observational longitudinal study including 230 persons with type 2 diabetes (T2D).RESULTS: Mean age at follow-up was 66.7 (SD 8.5) years, 30.5{\%} were women and mean body mass index (BMI) was 31.8 (4.4) kg/m2. Carotid IMT was measured at baseline, after 18 months of intervention in the Copenhagen Insulin and Metformin Therapy (CIMT) trial and after a mean follow-up of 6.4 (1.0) years. Baseline carotid IMT, carotid IMT after 18 months' intervention, and CV risk factors (age, sex and baseline systolic blood pressure) gave the best prediction of carotid IMT (root mean-squared error of prediction of 0.106 and 95{\%} prediction error probability interval of -0.160, 0.204).CONCLUSIONS: Measures of carotid IMT combined with CV risk factors at baseline predicts attained carotid IMT better than measures of carotid IMT or CV risk factors alone. Carotid IMT did not predict CV events, and the present results do not support the use of carotid IMT as a predictor of CV events in persons with T2D.",
keywords = "Ageing, Atherosclerosis, Cardiovascular disease, Cardiovascular risk factors, Carotid intima-media thickness, Prediction, Type 2 diabetes",
author = "Karoline Winckler and Birger Thorsteinsson and Niels Wiinberg and Jensen, {Andreas Kryger} and Louise Lundby-Christensen and Heitmann, {Berit Lilienthal} and Lund, {S{\o}ren S} and Thure Krarup and Tonny Jensen and Henrik Vestergaard and Leif Breum and Simone Sneppen and Trine Boesgaard and Sten Madsbad and Christian Gluud and Allan Vaag and Almdal, {Thomas P} and Lise Tarnow and {CIMT Trial group}",
note = "Copyright {\circledC} 2020 Elsevier Inc. All rights reserved.",
year = "2020",
month = "10",
doi = "10.1016/j.jdiacomp.2020.107681",
language = "English",
volume = "34",
pages = "107681",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc",
number = "10",

}

RIS

TY - JOUR

T1 - Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

AU - Winckler, Karoline

AU - Thorsteinsson, Birger

AU - Wiinberg, Niels

AU - Jensen, Andreas Kryger

AU - Lundby-Christensen, Louise

AU - Heitmann, Berit Lilienthal

AU - Lund, Søren S

AU - Krarup, Thure

AU - Jensen, Tonny

AU - Vestergaard, Henrik

AU - Breum, Leif

AU - Sneppen, Simone

AU - Boesgaard, Trine

AU - Madsbad, Sten

AU - Gluud, Christian

AU - Vaag, Allan

AU - Almdal, Thomas P

AU - Tarnow, Lise

AU - CIMT Trial group

N1 - Copyright © 2020 Elsevier Inc. All rights reserved.

PY - 2020/10

Y1 - 2020/10

N2 - AIMS: To investigate measures of carotid intima-media thickness (IMT) and conventional cardiovascular (CV) risk factors as predictors of future carotid IMT, and the prediction of CV events during follow-up based on measures of carotid IMT.METHODS: Observational longitudinal study including 230 persons with type 2 diabetes (T2D).RESULTS: Mean age at follow-up was 66.7 (SD 8.5) years, 30.5% were women and mean body mass index (BMI) was 31.8 (4.4) kg/m2. Carotid IMT was measured at baseline, after 18 months of intervention in the Copenhagen Insulin and Metformin Therapy (CIMT) trial and after a mean follow-up of 6.4 (1.0) years. Baseline carotid IMT, carotid IMT after 18 months' intervention, and CV risk factors (age, sex and baseline systolic blood pressure) gave the best prediction of carotid IMT (root mean-squared error of prediction of 0.106 and 95% prediction error probability interval of -0.160, 0.204).CONCLUSIONS: Measures of carotid IMT combined with CV risk factors at baseline predicts attained carotid IMT better than measures of carotid IMT or CV risk factors alone. Carotid IMT did not predict CV events, and the present results do not support the use of carotid IMT as a predictor of CV events in persons with T2D.

AB - AIMS: To investigate measures of carotid intima-media thickness (IMT) and conventional cardiovascular (CV) risk factors as predictors of future carotid IMT, and the prediction of CV events during follow-up based on measures of carotid IMT.METHODS: Observational longitudinal study including 230 persons with type 2 diabetes (T2D).RESULTS: Mean age at follow-up was 66.7 (SD 8.5) years, 30.5% were women and mean body mass index (BMI) was 31.8 (4.4) kg/m2. Carotid IMT was measured at baseline, after 18 months of intervention in the Copenhagen Insulin and Metformin Therapy (CIMT) trial and after a mean follow-up of 6.4 (1.0) years. Baseline carotid IMT, carotid IMT after 18 months' intervention, and CV risk factors (age, sex and baseline systolic blood pressure) gave the best prediction of carotid IMT (root mean-squared error of prediction of 0.106 and 95% prediction error probability interval of -0.160, 0.204).CONCLUSIONS: Measures of carotid IMT combined with CV risk factors at baseline predicts attained carotid IMT better than measures of carotid IMT or CV risk factors alone. Carotid IMT did not predict CV events, and the present results do not support the use of carotid IMT as a predictor of CV events in persons with T2D.

KW - Ageing

KW - Atherosclerosis

KW - Cardiovascular disease

KW - Cardiovascular risk factors

KW - Carotid intima-media thickness

KW - Prediction

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85088931861&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2020.107681

DO - 10.1016/j.jdiacomp.2020.107681

M3 - Journal article

VL - 34

SP - 107681

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 10

M1 - 107681

ER -

ID: 60568932